Honey based treatment strategies for infected wounds and burns: A systematic review of recent pre-clinical research

Krishnakumar, Gopal Shankar; Mahendiran, Balaji; Gopalakrishnan, Subiksha; Muthusamy, Shalini; Elangovan, Sinduja Malarkodi

doi:10.1016/j.wndm.2020.100188

Cited by 27 publications

(29 citation statements)

References 83 publications

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“…This fact highlights the importance of selecting an appropriate variety of honey, which means that a previous screening is necessary in order not only to quantify but also to determine profiles of bioactive substances [19,30]. In addition, it is necessary to consider that, although minor, there is a possibility that honey might induce negative effects, either by ingestion [122,123] or by topical use, mainly related to the presence of Clostridium botulinum spores, which have occasionally been found in honey [19,124,125]; however, to date, no cases of wound infection due to C. botulinum spores related to the use of non-irradiated honey were reported. Moreover, honey for medical uses must be free of any form of contamination, such as herbicides, pesticides, heavy metals, and spores-to meet all these criteria, honey must be collected in organic regions, as well as following strict quality, processing, and storage standards and regulations, in order to ensure its safety [108].…”

Section: Limitations Of the Use Of Honey In Therapymentioning

confidence: 99%

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

et al. 2020

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Antibacterial resistance has become a challenging situation worldwide. The increasing emergence of multidrug-resistant pathogens stresses the need for developing alternative or complementary antimicrobial strategies, which has led the scientific community to study substances, formulas or active ingredients used before the antibiotic era. Honey has been traditionally used not only as a food, but also with therapeutic purposes, especially for the topical treatment of chronic-infected wounds. The intrinsic characteristics and the complex composition of honey, in which different substances with antimicrobial properties are included, make it an antimicrobial agent with multiple and different target sites in the fight against bacteria. This, together with the difficulty to develop honey-resistance, indicates that it could become an effective alternative in the treatment of antibiotic-resistant bacteria, against which honey has already shown to be effective. Despite all of these assets, honey possesses some limitations, and has to fulfill a number of requirements in order to be used for medical purposes.

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Section: Limitations Of the Use Of Honey In Therapymentioning

confidence: 99%

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

et al. 2020

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“…Several studies have demonstrated, in vitro and in vivo, the efficacy of different varieties of honey against a broad spectrum of bacteria, including those that commonly caused wound and burn infections, such as Staphylococcus aureus , Pseudomonas aeruginosa , Escherichia coli , Acinetobacter baumannii , or Staphylococcus epidermidis [ 6 , 18 , 37 , 38 , 39 , 40 ]. In addition, honey has also been demonstrated to be effective against antibiotic-resistant bacteria [ 19 , 41 , 42 , 43 ], as well as against biofilms by preventing the formation and the development of the biofilm [ 31 , 44 , 45 , 46 , 47 ], by reducing the metabolic activity of already formed biofilms [ 44 , 48 ], or by altering the gene expression of different genes related to the formation and the development of biofilms [ 48 , 49 ], and is related to the bacterial quorum sensing [ 49 , 50 ].…”

Section: The Mechanisms Of Honey In Wound and Burn Healingmentioning

confidence: 99%

“…Another advantage of the anti-inflammatory action of honey is the decrease in edema, thus reducing the pressure on the microvasculature of wound tissue that allows the availability of oxygen and nutrients required for growth of tissue and wound repair [ 20 ]. This effect also allows the control of the wounds’ exudate with an appropriate moisture balance, which is still a constant challenge in the healing processes [ 39 ].…”

Section: The Mechanisms Of Honey In Wound and Burn Healingmentioning

confidence: 99%

“…The moist environment produced by honey facilitates the wounds´ autolytic debridement process. The high osmotic pressure pulls out lymphatic fluid from the deeper zones, which automatically remove dead, damaged, or infected scar tissue [ 27 , 39 ]. In addition, lymph is a rich source of proteases that activated by the hydrogen peroxide produced when honey is diluted and assists in the debriding activity [ 6 ].…”

Section: The Mechanisms Of Honey In Wound and Burn Healingmentioning

confidence: 99%

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Role of Honey in Advanced Wound Care

et al. 2021

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Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflammatory, and antimicrobial potential. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can influence the healing properties, also highlighting promising results in in vitro and in vivo trials. The challenges in the use of honey for wound healing are also covered and discussed. The delivery methodology (direct application, incorporated in fibrous membranes and hydrogels) is also presented and discussed.

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“…This adverse effect is dependent on the severity and protocol of chemotherapy and can potentially be life-threat-GMJ.2021;10:e1972 www.gmj.ir ening [2]. Honey is chiefly composed of sugar and water but contains a diverse range of vitamins, minerals, enzymes, and organic compounds [3]. Limited studies have elucidated the positive impact of honey on the prevention of febrile neutropenia (FN) in both children and adults [2,4], though no effects on red blood cell (RBC) and platelet levels have been discovered among adults.…”

Section: Introductionmentioning

confidence: 99%

Impact of Jollab on Blood Parameters in Patients with Breast Cancer Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

Ahadi

Pasalar

Gharehgozlou

et al. 2021

GMJ

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Background: In cancer patients, a prominent side effect of chemotherapy drugs is bone marrow suppression, which leads to decreased blood cell production. Herbal remedies and natural substances such as honey may fulfill a role in relieving this complication. The present study aimed to determine the efficiency of Jollab (a honey-based syrup) in the prevention of pancytopenia in female patients with breast cancer undergoing chemotherapy. Materials and Methods: In a pilot double-blinded, randomized, placebo-controlled clinical trial, 70 patients were examined in terms of leukocyte count, platelet count, and hemoglobin level at the Shohaday-e Tajrish Cancer Clinic (Tehran, Iran) in 2020. The intervention group consumed 10 ml of Jollab syrup three times a day for four weeks, while the control group took a placebo with the same prescription. The independent sample t-test and chi-squared test were used for data analysis in this trial. Results: Our data revealed that the total number of leukocytes, hemoglobin levels, and platelet counts have no significant differences between the two groups at the end of the study, but significant changes were discovered for hemoglobin and platelet levels in intragroup analysis for both intervention and placebo groups. Conclusion: Although the use of Jollab was not found to be effective in augmenting the levels of blood cell parameters in women with breast cancer undergoing chemotherapy, future studies of higher quality may demonstrate its supportive role provided the present limitations are addressed. [GMJ.2021;10:e1972]

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Honey based treatment strategies for infected wounds and burns: A systematic review of recent pre-clinical research

Cited by 27 publications

References 83 publications

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

Role of Honey in Advanced Wound Care

Impact of Jollab on Blood Parameters in Patients with Breast Cancer Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

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