2021
DOI: 10.1186/s12906-020-03170-5
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Honey and its nutritional and anti-inflammatory value

Abstract: Inflammation is the main key role in developing chronic diseases including cancer, cardiovascular diseases, diabetes, arthritis, and neurodegenerative diseases which possess a huge challenge for treatment. With massively compelling evidence of the role played by nutritional modulation in preventing inflammation-related diseases, there is a growing interest into the search for natural functional foods with therapeutic and preventive actions. Honey, a nutritional healthy product, is produced mainly by two types … Show more

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Cited by 156 publications
(108 citation statements)
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References 135 publications
(59 reference statements)
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“…The study of honey has also been of great interest for its biological and clinical actions against chronic diseases mediated by inflammation, such as cardiovascular, neurodegenerative, and arthritic. The study of the bioavailability of phenolic compounds in honey has made it possible to have an application in the treatment of inflammatory pathways in disorders of the gastrointestinal tract, edema, cancer, metabolic and cardiovascular diseases, and gut microbiota [ 33 ]. The absorption of polyphenols in the upper gastrointestinal tract is relatively low, which is why they tend to accumulate in the colon, and they can change the intestinal ecology [ 34 ], some bacterial groups may be limited, others can thrive in the niche of the accessible biome impacting the health of the host [ 35 ].In this sense, it has been shown that phenolic compounds can improve the survival and adhesion capacity of probiotics in conditions similar to the gastrointestinal tract, improving a variety of biochemical markers and risk factors for chronic diseases [ 36 ].…”
Section: The Phenolic Compounds Of Honeymentioning
confidence: 99%
“…The study of honey has also been of great interest for its biological and clinical actions against chronic diseases mediated by inflammation, such as cardiovascular, neurodegenerative, and arthritic. The study of the bioavailability of phenolic compounds in honey has made it possible to have an application in the treatment of inflammatory pathways in disorders of the gastrointestinal tract, edema, cancer, metabolic and cardiovascular diseases, and gut microbiota [ 33 ]. The absorption of polyphenols in the upper gastrointestinal tract is relatively low, which is why they tend to accumulate in the colon, and they can change the intestinal ecology [ 34 ], some bacterial groups may be limited, others can thrive in the niche of the accessible biome impacting the health of the host [ 35 ].In this sense, it has been shown that phenolic compounds can improve the survival and adhesion capacity of probiotics in conditions similar to the gastrointestinal tract, improving a variety of biochemical markers and risk factors for chronic diseases [ 36 ].…”
Section: The Phenolic Compounds Of Honeymentioning
confidence: 99%
“…These honeys can act as both bacteriostatic and bactericidal depending on the concentration used. Pasture honey (4-8%) and 5-11% manuka honey were found to be bacteriostatic, whereas bactericidal activity was achieved at 5-10% and 8-15% concentrations, respectively [15,27,67]. In contrast, artificial honey (sugar solution which mimics the composition of honey) showed only bacteriostatic activity (at 20-30% v/v) and not bactericidal in the study of Bansal et al (2005) [68].…”
Section: Discussionmentioning
confidence: 99%
“…The fathers of medicine in classical antiquity mention honey as an excellent medicine for burns and trauma management [13,14]. Being a popular therapeutic in many cultures, honey is considered ideal for gastric and other ailments [15,16]. Chemically, honey is a supersaturated solution of carbohydrates (90-95% of its dry matter) containing no more than 20% of water (usually 17%) [17].…”
Section: Introductionmentioning
confidence: 99%
“…It exhibits positive results when it comes to suppressing the production of NF-kB, MAPK (transcription factors), IL-6 and IL-1β (cytokines). On the other hand, regarding the inflammatory mediators, it has been evidenced that honey stimulates their production [2,92].…”
Section: Antioxidant and Anti-inflammatory Effectmentioning
confidence: 99%