Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds

Alam, Fahmida; Islam, Asiful; Gan, Siew Hua; Khalil, Md. Ibrahim

doi:10.1155/2014/169130

Cited by 94 publications

(91 citation statements)

References 156 publications

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“…Over many years, honey from diferent parts of the world have been shown to be one of the highest potential natural products in which phenolics, lavonoids, ascorbic acids, and some enzymes serve as potent antioxidants [32]. The antioxidant properties of honey are derived from both enzymatic (e.g., catalase, glucose oxidase, and peroxidase) and nonenzymatic substances (e.g., phenolic compounds, ascorbic acid, α-tocopherol, carotenoids, amino acids, proteins, and Maillard reaction products).…”

Section: Antioxidant Activitymentioning

confidence: 99%

The Value of Chilean Honey: Floral Origin Related to their Antioxidant and Antibacterial activities

Bridi¹,

Montenegro²

2017

Honey Analysis

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Honey chemical composition is related to the plant species where nectar is collected by honeybees. Chilean beekeeping is characterized by a variety of honey types, some unique, due to a high participation of endemic and native species. In Chile, the most emblematic lower honey, both for its abundance and sensory characteristics, is ulmo honey (Eucriphya cordifolia) and quillay honey (Quillaja saponaria). Melissopalynological analyses are used to establish whether a honey is uniloral, where at least 45% or more pollen grains found in it belong to the same species. The antioxidant and antimicrobial activities of Chilean honey have been studied in the last years with excellent results. Quillaja saponaria, Eucriphya cordifolia, Azara petiolaris, and Retanilla trinervia are within the Chilean endemic species that produce uniloral honeys that show antioxidant potential and antibacterial activity against pathogenic gram positive and gram -negative bacteria and also multiresistant strains. These activities are mainly atributed to the phenolic compounds such as lavonoids. Among these atractive characteristics of honey, it is important to note that this product has low toxicity and the medicinal properties of honey will help to protect honeybees by adding value not only to the signiicantly important process of pollinating crops and native plants, but also for the medicinal importance of their products.

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Section: Antioxidant Activitymentioning

confidence: 99%

The Value of Chilean Honey: Floral Origin Related to their Antioxidant and Antibacterial activities

Bridi¹,

Montenegro²

2017

Honey Analysis

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“…It has been suggested that iodine has a negative impact on cells involved in the wound healing process and because of this its safety and efficacy have been questioned [24]. In contrast, the honey-based product showed excellent cytocompatibility with tissue cell cultures [29] and for long term use as in the management of chronic foot ulcers proved to be efficacious, cost-effective, and acceptable by both clinicians and patients [30].…”

Section: Discussionmentioning

confidence: 99%

Use of Honey in Management of Diabetic Foot Infection: Patient’s Satisfaction and Outcome

Kosternoy¹

2015

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Abstract:Introduction: diabetic foot is a major economic problem, and its management has not always been performed in a most cost effective way. This study on diabetic foot infection aimed at comparison of the effect of bee honey with another concentrated carbohydrate solution like glycerin and with a group using betadine and saline. Patients, Materials and Methods: The patients were divided into three groups; Group A: dressing with bee honey, Group B: dressing with glycerin magnesia and Group C: represented the control group dressed with Betadine and Saline. Results: We observed that the tested materials had positive effects on diabetic foot infections but honey surpassed all by reducing the debridement times and the load of infecting organisms. Conclusion: Local wound care plays a good role when topically applied to treat diabetic foot wounds. Honey seems effective in combating infection and helps wound healing.

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“…Clinical studies and bioactivity demonstrate the eiciency of honey in wound healing, maintaining a moist environment, promoting drainage of wound exudate and autolytic debridement [144]. It has been reported in minimizing malodour and scar formation of the wound [145] as well as angiogenic activity [146].…”

Section: Honey Dressingsmentioning

confidence: 99%

“…Van den "erg et al [142] investigated the anti-inlammatory properties of diferent types of honey in vitro by testing reactive oxygen species (ROS) inhibition capability and found "merican buckwheat honey exhibits high ROS inhibition ability. Many clinical studies have been performed on the basis of the antimicrobial efect of honey [143][144][145]. Clinical studies and bioactivity demonstrate the eiciency of honey in wound healing, maintaining a moist environment, promoting drainage of wound exudate and autolytic debridement [144].…”

Section: Honey Dressingsmentioning

confidence: 99%

Antimicrobial Dressings for Improving Wound Healing

Sarheed¹,

Ahmed²,

Shouqair³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

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Wound healing occurs by a series of interrelated molecular events which work together to restore tissue integrity and cellular function. These physiological events occur smoothly in normal healthy individual and/or under normal conditions. However, in certain cases, these molecular events are retarded resulting in hard-to-heal or chronic wounds arising from several factors such as poor venous return, underlying physiological or metabolic conditions such as diabetes as well as external factors such as poor nutrition. In most cases, such wounds are infected and infection also presents as another complicating phenomenon which triggers inlammatory reactions, therefore delaying wound healing. There has therefore been recent interests and signiicant eforts in preventing and actively treating wound infections by directly targeting infection causative agents through direct application of antimicrobial agents either alone or loaded into dressings (medicated). These have the advantage of overcoming challenges such as poor circulation in diabetic and leg ulcers when administered systemically and also require lower amounts to be applied compared to that required via oral or iv administration. This chapter will review and evaluate various antimicrobial agents used to target infected wounds, the means of delivery, and current state of the art, including commercially available dressings. Data sources will include mainly peer-reviewed literature, clinical trials and reports, patents as well as government reports where available.

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Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds

Cited by 94 publications

References 156 publications

The Value of Chilean Honey: Floral Origin Related to their Antioxidant and Antibacterial activities

The Value of Chilean Honey: Floral Origin Related to their Antioxidant and Antibacterial activities

Use of Honey in Management of Diabetic Foot Infection: Patient’s Satisfaction and Outcome

Antimicrobial Dressings for Improving Wound Healing

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