Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population

Lye, Munn-Sann; Visuvanathan, Shaneeta; Chong, Pei Pei; Yap, Yoke-Yeow; Lim, Chin-Chye; Ban, Eng-Zhuan

doi:10.1371/journal.pone.0130530

Cited by 10 publications

(7 citation statements)

References 55 publications

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“…The characteristics of the included studies are in Tables and . A total of 23 case–control studies (Ban et al., ; Chen et al., ; Cheng et al., ; Ekburanawat et al., ; Fachiroh et al., ; Ghosh et al., ; Ji et al., ; Khlifi et al., ; Lakhanpal et al., ; Lo et al., ; Lye et al., ; Mabuchi et al., ; Nong et al., ; Polesel et al., ; Shanmugaratnam et al., ; Sriamporn et al., ; Wei et al., ; Yang et al., ; Yong et al., ; Yuan et al., ; Zhang et al., ; Zou et al., , ) and 2 cohort studies (Friborg et al., ; Li et al., ) were included in the overall meta‐analysis. The other 5 studies (Nam et al., ; Ruan et al., ; Vaughan, ; Vaughan et al., ; Yu et al., ) did not include information on ever drinkers versus nondrinkers, so they were used only in the subgroup analysis of drinking‐related characteristics associated with NPC risk.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, our findings agree with a previous meta‐analysis (Li et al., ). Because of the insufficiency of included studies, different literature quality, and unreasonable classification methods in this previous meta‐analysis (Li et al., ), the results should be reviewed again with new studies (Ban et al., ; Fachiroh et al., ; Ghosh et al., ; Khlifi et al., ; Lakhanpal et al., ; Lo et al., ; Lye et al., ; Xu et al., ; Yong et al., ). The many confounding factors and design differences in the current included studies led to different results.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies

Chen

Zheng

et al. 2019

Alcoholism Clin & Exp Res

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Background: Alcohol consumption is increasing all over the world, but whether it is an independent factor affecting the occurrence of nasopharyngeal carcinoma (NPC) is inconsistent in many studies. We aimed to explore the association between alcohol consumption and NPC risk by integrating existing evidence in a meta-analysis.Methods: We searched for relevant articles published up to August 2018 in PubMed, Cochrane Library, Web of Science, and China National Knowledge infrastructure (CNKI). The Newcastle-Ottawa scale was used to assess the quality of the included studies. Odds ratios (ORs) or relative risks were pooled to estimate the associations between alcohol consumption and NPC risk.Results: The meta-analysis of cohort studies showed no significant association between alcohol consumption and NPC, but pooled results from case-control studies indicated that ever drinking increased the probability of NPC versus nondrinking (OR = 1.10; 95% confidence interval [CI]: 1.01, 1.19). As compared with nondrinkers, high-frequency drinking (≥7 times/wk) increased the NPC probability (OR = 1.29; 95% CI: 1.05, 1.53) and low-frequency drinking (<7 times/wk) decreased the probability (OR = 0.77; 95% CI: 0.60, 0.94), as did shorter duration of drinking (<20 years) (OR = 0.64; 95% CI: 0.49, 0.79). On subgroup analyses, significant pooled results were observed for studies with high quality, with hospital-based controls and with adjustment for confounding factors, smoking, age, and sex.Conclusions: The risk of NPC may increase with alcohol consumption. Ever drinking increased the risk versus nondrinking. Additionally, high-frequency drinking increased the risk, but low-frequency drinking decreased it to some extent. Further intensive studies based on well-designed methods are needed to examine the association.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies

Chen

Zheng

et al. 2019

Alcoholism Clin & Exp Res

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“…More than 100 mutations have been mapped in XPD [ 41 ], which could potentially affect the helicase activity of the encoded protein, thereby impeding normal NER function and leading to increased cancer risk [ 29 , 42 ]. Several XPD polymorphisms are reportedly associated with cancer risk [ 43 – 45 ]. Among these, rs1799793 (Asp312Asn) and rs13181 (Lys751Gln) in the XPD coding region are the two most widely investigated.…”

Section: Discussionmentioning

confidence: 99%

Relevance of XPD polymorphisms to neuroblastoma risk in Chinese children: a four-center case-control study

Cheng

Zhang

Xin

et al. 2018

Aging

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Neuroblastoma is a lethal tumor that commonly occurs in children. Polymorphisms in XPD reportedly influence risk for several types of cancer, though their roles in neuroblastoma remain unclear. Here we endeavored to determine the relevance of XPD gene polymorphisms and neuroblastoma susceptibility in Chinese children genotyping three XPD polymorphisms (rs3810366, rs13181 and rs238406) in 505 cases and 1070 controls and assessing their contributions to neuroblastoma risk. Overall, we detected no significant association between any single XPD genotype and neuroblastoma risk. When risk genotypes were combined, however, we found that patients with 2-3 risk genotypes were more likely to develop neuroblastoma (adjusted odds ratio =1.31; 95% confidence interval =1.06-1.62, P=0.013) than those with 0-1 risk genotypes. Stratification analysis of rs3810366 revealed significant relationships between the subgroups age ≤18 months and clinical stage I+II+4s and neuroblastoma risk. Moreover, the presence of 2-3 risk genotypes was significantly associated with increased neuroblastoma risk in the subgroups age ≤18 months, male, tumor originated from others, and clinical stage I+II+4s. Our findings provide novel insight into the genetic underpinnings of neuroblastoma and demonstrate that XPD polymorphisms may have a cumulative effect on neuroblastoma risk.

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“…A significant association was found between XPD Lys751Gln polymorphism and the odds of NPC. The effect of this individual polymorphism has been discussed extensively in our previous publication [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…XPD Lys751Gln polymorphism is located in carboxy terminal domain (CTD) where XPD-p44 interaction takes place [ 27 ]. XPD homozygous wildtype Lys/Lys genotype has been shown to be associated with higher odds of NPC (OR = 1.58, 95% CI = 1.05–2.38, p = 0.028) [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia

et al. 2017

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Background8-oxoG, a common DNA lesion resulting from reactive oxygen species (ROS), has been shown to be associated with cancer initiation. hOGG1 DNA glycosylase is the primary enzyme responsible for excision of 8-oxoG through base excision repair (BER). Integrins are members of a family of cell surface receptors that mediate the cell-cell and extracellular matrix (ECM) interactions. Integrins are involved in almost every aspect of carcinogenesis, from cell differentiation, cell proliferation, metastasis to angiogenesis. Loss of ITGA2 expression was associated with enhanced tumor intravasation and metastasis of breast and colon cancer. XPD gene encodes DNA helicase enzyme that is involved in nucleotide excision repair (NER). It is shown in previous research that XPD homozygous wildtype Lys/Lys genotype was associated with higher odds of NPC.MethodsWe conducted a 1 to N case-control study involving 300 nasopharyngeal carcinoma (NPC) cases and 533 controls matched by age, gender and ethnicity to investigate the effect of hOGG1 Ser326Cys, ITGA2 C807T and XPD Lys751Gln polymorphisms on NPC risk. Linkage disequilibrium and haplotype analysis were conducted to explore the association of allele combinations with NPC risk. Restriction fragment length polymorphism (RFLP-PCR) was used for DNA genotyping.ResultsNo significant association was observed between hOGG1 Ser326Cys and ITGA2 C807T polymorphisms with NPC risk after adjustment for age, gender, ethnicity, cigarette smoking, alcohol and salted fish consumption. Lys/Lys genotype of XPD Lys751Gln polymorphism was associated with increased NPC risk (OR = 1.60, 95% CI = 1.06–2.43). Subjects with history of smoking (OR = 1.81, 95% CI = 1.26–2.60), and salted fish consumption before age of 10 (OR = 1.77, 95% CI = 1.30–2.42) were observed to have increased odds of NPC. The odds of developing NPC of CGC haplotype was significantly higher compared to reference AGC haplotype (OR = 2.20, 95% CI = 1.06–4.58).ConclusionThe allele combination of CGC from hOGG1, ITGA2 and XPD polymorphisms was significantly associated with increased odds of NPC.

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Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population

Cited by 10 publications

References 55 publications

Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies

Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies

Relevance of XPD polymorphisms to neuroblastoma risk in Chinese children: a four-center case-control study

Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia

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