Homozygous deletions at 3p12 in breast and lung cancer

Sundaresan, Vasi; Chung, Grace Tin‐Yun; Heppell-Parton, A.; Xiong, Jeinying; Grundy, Catherine B.; Roberts, Ian; James, Louise A; Cahn, Anthony; Bench, Anthony J.; Douglas, Jenny; Minna, John D.; Sekido, Yoshitaka; Lerman, Michael I.; Latif, Farida; Bergh, Jonas; Li, Hua; Lowe, Nick; Ogilvie, Donald; Rabbitts, Pamela

doi:10.1038/sj.onc.1202103

Cited by 92 publications

(79 citation statements)

References 22 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is noteworthy that a case of uveal melanomas has been previously described with a translocation at 3p13 as the sole abnormality, suggesting that a second important TSG may reside at this location. 16 Furthermore, DUTT1/ ROBO1 is a putative TSG located within the deleted region identified in the present study, 22,23 the expression of which is absent in uveal melanomas with monosomy 3. 21 DUTT1/ROBO1 is a neural cell adhesion molecule, as is CHL1 at 3p26, and represents a target for further study as a candidate TSG in the preferentially deleted region around 3p12-13.…”

Section: Discussionmentioning

confidence: 57%

Multiple locations on chromosome 3 are the targets of specific deletions in uveal melanoma

Cross

Ganesh

Parpia

et al. 2005

Eye

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 57%

Multiple locations on chromosome 3 are the targets of specific deletions in uveal melanoma

Cross

Ganesh

Parpia

et al. 2005

Eye

View full text Add to dashboard Cite

“…In lung tumor cell lines, homozygous deletions have been characterized in regions 3p12, 3p14 and 3p21, for instance in cell line U2020. 116 Interestingly, ROBO1/ Dutt1 was mapped within the deletion and its promoter region is hypermethylated in primary lung, renal and breast tumors. So far, no somatic point mutation of ROBO1 (or of its ligands slits) was reported in tumors.…”

Section: The Slits and Robosmentioning

confidence: 99%

The brain within the tumor: new roles for axon guidance molecules in cancers

2005

View full text Add to dashboard Cite

Slits, semaphorins and netrins are three families of proteins that can attract or repel growing axons and migrating neurons in the developing nervous system of vertebrates and invertebrates. Recent studies have shown that they are widely expressed outside the nervous system and that they may play important roles in cancers. Several of the genes encoding these proteins are localized on chromosomal region associated with frequent loss-of-heterozygosity in tumors and cancer cell lines and there is also significant hypermethylation of their promoter suggesting that they may act as tumor suppressors. In addition, proteins in all these families and their receptors appear to control the vascularization of the tumors. Last, many axon guidance molecules also regulate cell migration and apoptosis in normal and tumorigenic tissues. Overall, this suggests that molecules that could mimick or block the activity of axon guidance molecules may be used as therapeutic agents for the treatment of malignancy.

show abstract

“…High-resolution studies of tumours refined the areas of allelic losses in 3p into several distinct regions representing likely locations of tumour-suppressor genes (TSGs). These candidate regions include 3p12-13, 3p14.2, 3p21.3, 3p24-25 and 3p25-26 (Hung et al, 1995;Sekido et al, 1998;Sundaresan et al, 1998;Wistuba et al, 2000). Investigation of these regions has identified resident TSGs, for example VHL at 3p25 and FHIT at 3p14.2, or likely candidates such as DUTT1/ROBO1 at 3p12.…”

Section: Introductionmentioning

confidence: 99%