Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3‐3p21.3 in sporadic breast‐cancer development

Buchhagen, Dorothy L.; Qiu, Luping; Etkind, Polly R.

doi:10.1002/ijc.2910570406

Cited by 52 publications

(31 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The background (random) rate of LOH in the mammary gland has been reported as 4% (Chen et al, 1992), and previous reports suggest a frequency of LOH at certain sites in invasive carcinoma of 19-60% (Callahan and Campbell, 1989;Ben Cheickh et al, 1992;Mooi and Peterse, 1992;Takita et al, 1992). While the D3S1514 (3p2l-pl4.2; Buchhagen et al, 1994), D9S254 (9p23-p2l; Brenner and Aldaz, 1995) and THOI (lpIS.5; Winqvist et al, 1993;Gudmundsson et al, 1995) loci have been reported to be important in breast carcinogenesis, the FABP and SCA3 loci were chosen as being representative of chromosomal regions thought to be irrelevant to mammary carcinogenesis. In the invasive carcinomas studied here, a similarly low rate of LOH (9.1-13%) was observed at the D3S1514, FABP, D9S254, THOI and SCA3 loci, which is two to three times the background rate reported by Chen et al (1992).…”

Section: Resultsmentioning

confidence: 99%

Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors

Dillon

Boer²,

Papadimitriou³

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

Summary Microsatellite instability is a form of genetic damage that may be due to defective mismatch repair genes and may be a marker of processes leading to malignancy. We have analysed a series of epithelial hyperplasia of usual type, carcinomas in situ and invasive and metastatic carcinomas from the mammary gland on the assumption that they represent stages in the evolution of mammary carcinoma. Eight markers on chromosomes 3p, 4q, 9p, 11p, 14q, 17p, 17q and Xq were examined for microsatellite instability and loss of heterozygosity. High rates of loss on chromosomes 17p, 17q and Xq indicate that these chromosomal arms contain genes important in mammary carcinogenesis. The rate of microsatellite instability observed in this study was uniformly low, irrespective of the lesion. This implies that microsatellite instability is not a marker of malignancy in most instances of mammary neoplasia.

show abstract

Section: Resultsmentioning

confidence: 99%

Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors

Dillon

Boer²,

Papadimitriou³

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…lung cancer (Roche et al, 1996) and breast cancer (Buchhagen et al, 1994). Several genes with potential tumoursuppressing activity have been shown to locate to this region.…”

Section: Discussionmentioning

confidence: 99%

Loss of heterozygosity of 3p markers in neuroblastoma tumours implicate a tumour-suppressor locus distal to the FHIT gene

Ejeskär

Aburatani²,

Abrahamsson³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

Summary Neuroblastoma is a heterogeneous childhood tumour of the sympathetic nervous system, in which deletions of chromosomal region lp and amplification of the MYCN oncogene correlate with aggressive tumour behaviour. However, the majority of neuroblastoma tumours show neither of these aberrations, indicating that other chromosomal regions may be involved in tumorigenesis. Here, we report findings of loss of heterozygosity (LOH) on chromosome 3. In our neuroblastoma material, nine of 59 (15.3%) tested tumours showed allelic loss of chromosome 3p markers. We found significant clinical and biological differences between tumours with the loss of one entire chromosome 3 vs tumours with partial loss in chromosome region 3p. All children with tumours with whole chromosome 3 loss are long-term survivors, whereas all children with tumours showing partial 3p LOH have died from tumour progression. A consensus region found to be deleted in all the tumours with 3p deletions was defined by markers D3S1286 and D3S1295, i.e. 3p25.3-p14.3, distal to the FHIT gene.

show abstract

“…The FLpter value was 0.27+0.02 corresponding to a localization for BAP1 at 3p21.2-p21.31. This location is a region of LOH for breast cancer as well as a region frequently deleted in lung carcinomas (Buchhagen et al, 1994;Thiberville et al, 1995).…”

Section: Bap1 Is Located On Chromosome 3p213 and Is Mutated In Non-smentioning

confidence: 99%

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

et al. 1998

View full text Add to dashboard Cite

We have identi®ed a novel protein, BAP1, which binds to the RING ®nger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclearlocalized, ubiquitin carboxy-terminal hydrolase, suggesting that deubiquitinating enzymes may play a role in BRCA1 function. BAP1 binds to the wild-type BRCA1-RING ®nger, but not to germline mutants of the BRCA1-RING ®nger found in breast cancer kindreds. BAP1 and BRCA1 are temporally and spatially coexpressed during murine breast development and remodeling, and show overlapping patterns of subnuclear distribution. BAP1 resides on human chromosome 3p21.3; intragenic homozgyous rearrangements and deletions of BAP1 have been found in lung carcinoma cell lines. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth and is the ®rst nuclearlocalized ubiquitin carboxy-terminal hydrolase to be identi®ed. BAP1 may be a new tumor suppressor gene which functions in the BRCA1 growth control pathway.

show abstract

Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3‐3p21.3 in sporadic breast‐cancer development

Cited by 52 publications

References 20 publications

Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors

Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors

Loss of heterozygosity of 3p markers in neuroblastoma tumours implicate a tumour-suppressor locus distal to the FHIT gene

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

Contact Info

Product

Resources

About