Homozygosity for killer immunoglobin-like receptor haplotype A predicts complete molecular response to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients

Killer immunoglobulin-like receptors can predict TKI treatment-free remission in chronic myeloid leukemia patients

“…To our knowledge, no data have so far been published on the potential influence of KIR receptors on TFR. In a previous report, we found a significant association between homozygosity for the KIR A haplotype and achievement of MR 4.5 [14]. The present study suggests a favorable role for the KIR AA genotype in maintaining molecular remission in patients after TKI cessation.…”

“…In a previous report, we found that homozygosity for KIR A haplotype was significantly associated with achievement of molecular response (MR 4.5 ) [14]. In the present study, we investigated whether KIR genes and/or KIR haplotypes could represent predictive immune biomarkers of stable TFR in CML.…”

KIR2DL5B genotype predicts outcomes in CML patients treated with response-directed sequential imatinib/nilotinib strategy

“…21 Additionally, certain KIR genotypes have previously been reported to be overrepresented in CML patients. 22 However, KIR genotype frequencies observed in our cohort are similar to those observed in other Caucasian populations reported in the Allele Frequency Database.…”

NK Cell Genotype and Phenotype at Diagnosis of Acute Lymphoblastic Leukemia Correlate with Postinduction Residual Disease

“…However, others corroborate our findings of an A haplotype benefit and a B haplotype disadvantage(22, 23). The A haplotypes were associated with a complete molecular response in chronic myeloid leukemia(24) and an improved disease free survival in patients receiving a haploidentical T-cell depleted stem cell transplant for leukemia. The risk of relapse in the latter study increased with the number of activating donor KIR genes present(25).…”