Homotransplantation of Kidney in Patients Treated by Preoperative Local Irradiation and Postoperative Administration of an Antimetabolite (Imuran)

Chronic Survival After Human Renal Homotransplantation Lymphocyte-Antigen Matching, Pathology and Influence of Thymectomy

“…Because of the known hepatotoxicity of azathioprine g, 69 ing the total to 9 ( Table 9 ) . In six patients it has been possible to disLate rejection occurred 112 to 390 days continue prednisone with continuing stable after transplantation, and in all but one renal function for the ensuing 3 to 21 patient it was controlled by resumption months (Fig.…”

Evolution of Liver Transplantation

“…Because the first genuinely promising drug, azathioprine (8), proved to be effective only rarely when given alone (69), the "modern" era was not entered until it was realized that azathioprine and prednisone have an additive (or possibly synergistic) effect (67, [70][71][72][73]. At the outset, our policy was to begin therapy after renal transplantation with azathioprine and to add high doses of prednisone with the first signs of rejection (70).…”

Renal Homotransplantation in 24 Patients

“…Several centres in Europe and the United States have made outstanding contributions to the clinical field, and encouraging results have been reported by Hume et al (1963), Merrill et al (1963), Shackman et al (1963, Woodruff et al (1963), and Starzl et al (1964a). Results obtained at the present time indicate that useful prolongation of life is possible in from 30 to 50% of patients having terminal renal failure.…”