“…This paper is thus a natural continuation of original Zariski's and van Kampen's papers [28,26] about the fundamental groups of the complements of plane algebraic curves (which are special cases of our main result); Chà eniot's papers [3,4] containing the ÿrst complete proof of the Zariski-van Kampen theorem, and [6] concerning similar problems for the high-dimensional homology groups of non-singular quasi-projective varieties; Libgober's and Chà eniot-Libgober's papers [19,8] about the high-dimensional homotopy groups of the complements of hypersurfaces with isolated singularities; Shimada's papers [21,22] on the fundamental groups of non-singular irreducible quasi-projective varieties; and the paper of Chà eniot and the author [7] concerning the high-dimensional homotopy groups of the complements of hypersurfaces with isolated singularities (note that [7] also gives a general conjecture concerning extensions of [19,8,7] to high-dimensional homotopy groups of non-singular quasi-projective varieties).…”