“…They have been previously implicated in the strain variability of Y. pestis, namely by RFLP analysis of the IS100 location (Achtman et al, 1999 ;McDonough & Hare, 1997), and their presence contributes to the instability of the pgm locus (Buchrieser et al, 1998 ;Fetherston & Perry, 1994). In E. coli, the majority of insertion sequences are associated with lateral gene transfer, and they are frequently located at junctions of native and transferred DNA (Lawrence & Ochman, 1998).…”