Homology modelling of human divalent metal transporter (DMT): Molecular docking and dynamic simulations for duodenal iron transport

Anantram, Aarti; Janve, Madhura; Degani, Mariam S.; Kundaikar, Harish

doi:10.1016/j.jmgm.2018.08.006

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…Cellular iron homeostasis is maintained by iron transport proteins that work in concert with a lot of enzymes and other cell elements. Duodenal enterocytes belong to cell types which are characterized by highly dynamic iron handling [29]. The intracellular machinery of iron absorption stimulation induced by the RBRJ compound complex is unclear.…”

Section: Discussionmentioning

confidence: 99%

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Babarykin¹,

Смирнова²,

Krumina³

et al. 2018

JBM

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Iron deficiency is one of the leading risk factors for disability and death worldwide. Targeted iron supplementation with pharmaceuticals is widely used, but oral iron salt ingestion often causes side effects-nausea, vomiting, abdominal pain. The present study demonstrated that red beetroot juice (RBRJ) contains a compound or compound complex with the ability to specifically stimulate duodenal iron absorption, shown in experiments in vitro, in situ and in vivo. The effect does not depend on juice sugar and ascorbic acid concentration. Fractionated RBRJ impact on iron absorption is dose dependent. This phenomenon is described for the first time.

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Section: Discussionmentioning

confidence: 99%

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Babarykin¹,

Смирнова²,

Krumina³

et al. 2018

JBM

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“…The expression of DMT1 isoforms is dependent on the cell type and subcellular distribution. The protein structure of human DMT1 is not available in PDB; however, the homology modeling has been reported [ 66 ]. The precise molecular mechanism underlying iron transport remains unclear.…”

Section: Redox-active Iron In Cells: Transit Iron Poolmentioning

confidence: 99%

Iron-Induced Oxidative Stress in Human Diseases

Kawabata

2022

Cells

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Iron is responsible for the regulation of several cell functions. However, iron ions are catalytic and dangerous for cells, so the cells sequester such redox-active irons in the transport and storage proteins. In systemic iron overload and local pathological conditions, redox-active iron increases in the human body and induces oxidative stress through the formation of reactive oxygen species. Non-transferrin bound iron is a candidate for the redox-active iron in extracellular space. Cells take iron by the uptake machinery such as transferrin receptor and divalent metal transporter 1. These irons are delivered to places where they are needed by poly(rC)-binding proteins 1/2 and excess irons are stored in ferritin or released out of the cell by ferroportin 1. We can imagine transit iron pool in the cell from iron import to the export. Since the iron in the transit pool is another candidate for the redox-active iron, the size of the pool may be kept minimally. When a large amount of iron enters cells and overflows the capacity of iron binding proteins, the iron behaves as a redox-active iron in the cell. This review focuses on redox-active iron in extracellular and intracellular spaces through a biophysical and chemical point of view.

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Staphylococcus capitis : insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species

Crepin,

Chavignon,

Verhoeven

et al. 2024

Clin Microbiol Rev

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SUMMARY Staphylococcus capitis is divided into two subspecies, S. capitis subsp. ureolyticus (renamed urealyticus in 1992; ATCC 49326) and S. capitis subsp. capitis (ATCC 27840), and fits with the archetype of clinically relevant coagulase-negative staphylococci (CoNS). S. capitis is a commensal bacterium of the skin in humans, which must be considered an opportunistic pathogen of interest particularly as soon as it is identified in a clinically relevant specimen from an immunocompromised patient. Several studies have highlighted the potential determinants underlying S. capitis pathogenicity, resistance profiles, and virulence factors. In addition, mobile genetic element acquisitions and mutations contribute to S. capitis genome adaptation to its environment. Over the past decades, antibiotic resistance has been identified for S. capitis in almost all the families of the currently available antibiotics and is related to the emergence of multidrug-resistant clones of high clinical significance. The present review summarizes the current knowledge concerning the taxonomic position of S. capitis among staphylococci, the involvement of this species in human colonization and diseases, the virulence factors supporting its pathogenicity, and the phenotypic and genomic antimicrobial resistance profiles of this species.

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Homology modelling of human divalent metal transporter (DMT): Molecular docking and dynamic simulations for duodenal iron transport

Cited by 5 publications

References 36 publications

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Iron-Induced Oxidative Stress in Human Diseases

Staphylococcus capitis : insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species

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Homology modelling of human divalent metal transporter (DMT): Molecular docking and dynamic simulations for duodenal iron transport

Cited by 5 publications

References 36 publications

Stimulating Effect of Red Beetroot (&lt;i&gt;Beta vulgaris&lt;/i&gt;) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Stimulating Effect of Red Beetroot (&lt;i&gt;Beta vulgaris&lt;/i&gt;) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Iron-Induced Oxidative Stress in Human Diseases

Staphylococcus capitis : insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species

Contact Info

Product

Resources

About

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines