Homologous Recombination Repair Deficiency in Metastatic Prostate Cancer: New Therapeutic Opportunities
Claudia Piombino,
Stefania Pipitone,
Elena Tonni
et al.
Abstract:More than 20% of metastatic prostate cancer carries genomic defects involving DNA damage repair pathways, mainly in homologous recombination repair-related genes. The recent approval of olaparib has paved the way to precision medicine for the treatment of metastatic prostate cancer with PARP inhibitors in this subset of patients, especially in the case of BRCA1 or BRCA2 pathogenic/likely pathogenic variants. In face of this new therapeutic opportunity, many issues remain unsolved. This narrative review aims to… Show more
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