Homologous Disease in the Adult Rat, a Model for Autoimmune Disease

Šťastný, Peter; Stembridge, Vernie A.; Vischer, Thomas L.; Ziff, Morris

doi:10.1084/jem.122.4.681

Cited by 26 publications

(2 citation statements)

References 35 publications

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“…Indeed, this possibility was foreseen in pioneering studies in animal models of graft versus host disease in the 1960s. 3 Chronic graft versus host disease appears between 70 and 400 days after transplantation and has well defined clinical features. Skin lesions are almost invariably present.…”

Section: Regular Reviewmentioning

confidence: 99%

Graft versus host diseases: new versions of old problems?

Denman¹

1985

BMJ

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replacement for at least a year, and even then conventional adult hormone replacement should not be contemplated for at least another year. To move more quickly than this causes development of the breasts which is almost entirely confined to the nipple and areola-which causes great unhappiness. Whether in such patients history can be rerun with advantage is far from clear.The problem with the medical care of patients in their teens is that in the hospital service such patients fall between the spheres of knowledge of physicians, including endocrinologists and oncologists, of gynaecologists, and of paediatricians. Family doctors may be more directly concerned, but unfortunately the education which most of us had on this difficult topic was woefully inadequate. Puberty is of such great importance to patients that abnormalities of it deserve early recognition and skilled, if not

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Section: Regular Reviewmentioning

confidence: 99%

Graft versus host diseases: new versions of old problems?

Denman¹

1985

BMJ

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“…In the present paper, the production and clinical features of homologous disease in the adult rat are described, and the histological and ~mmuno-logical reactions occurring in the skin are presented in detail. In a subsequent paper (16), changes in the joints, heart, and other organs will be presented.…”

Section: Homologous Diseasej Model For Autotm~rune Diseasementioning

confidence: 99%

Homologous Disease in the Adult Rat, a Model for Autoimmune Disease

Šťastný

Stembridge

Ziff

1963

The Journal of Experimental Medicine

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117

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The cutaneous lesions of adult rats with homologous disease are described, and evidence is presented to indicate that they have an immunologic basis. The skin changes included erythema, purpura, edema, and a variety of inflammatory lesions. In the more active lesions, dermal infiltration, hydropic degeneration, acanthosis, and atrophy of the epidermis with hyperkeratosis and follicular plugging were present. In some cases, ulceration and sloughing were also observed. More chronic lesions were characterized by atrophy of the epidermis and collagenization of the dermis with disappearance of the skin appendages. Rejection of autografts was observed simultaneously with acceptance of homografts. The histologic appearance of autografts undergoing rejection was similar to that of the spontaneous skin lesions, suggesting that the latter, too, had an immunologic basis. In favor of this, also, was the specificity of the dermatitis for the skin of the host, with sparing of neighboring homograft tissue. There was a histologic similarity between the spontaneous skin lesions of homologous disease and those of lupus erythematosus on the one hand, and scleroderma on the other, thus supporting the possibility that the cutaneous lesions of these connective tissue diseases of man may also have an immunologic basis. It was concluded that the adult rat with homologous disease may furnish a model for human autoimmune disease.

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Visceral lesions in an unusual case of sézary's syndrome

Paradinas

Harrison

1974

Cancer

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A 29‐year‐old woman with long‐standing thrombocytopenia due to megakaryocytic hypoplasia developed features of Sézary's syndrome associated with arthropathy and signs of peripheral vascular occlusion. She died 14 months later. At necropsy, cellular infiltrations including lymphocytes, histiocytes, plasma cells, and atypical mononuclear cells were found in the walls of small arteries and parenchyma of visceral organs as well as in the skin. The infiltrations had led to fibrosis and focal parenchymal damage which resembled that seen in experimental and iatrogenic graft‐vs.‐host reactions. In places there was a transition between these mixed cellular infiltrations and uniformly lymphocytic infiltrations with histologic features of a lymphoma.

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Homologous Disease in the Adult Rat, a Model for Autoimmune Disease

Cited by 26 publications

References 35 publications

Graft versus host diseases: new versions of old problems?

Graft versus host diseases: new versions of old problems?

Homologous Disease in the Adult Rat, a Model for Autoimmune Disease

Visceral lesions in an unusual case of sézary's syndrome

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