Homoleptic Poly(nitrato) Complexes of Group 14 Stable at Ambient Conditions

Portius, Peter; Peerless, Benjamin; Davis, Martin F.; Campbell, Rory

doi:10.1021/acs.inorgchem.6b01455

Cited by 8 publications

(4 citation statements)

References 42 publications

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“…The residual mass corresponds to formation of ZnO as the most possible end product for all three complexes . When compared with the published data, analogous thermoanalytical results have been observed suggesting that the chloride, nitrate, trifluoroacetate, and other carboxylate-based metal complexes release Cl 2 , NO 2 , CHF 3 , and CO 2 gases upon thermal decomposition. − …”

Section: Resultssupporting

confidence: 66%

Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus

Majumder

Sarkar

Das

et al. 2023

ACS Appl. Mater. Interfaces

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A novel class of zinc(II)-based metal complexes, i.e., [Zn 2 (acdp)(μ-Cl)]•2H 2 O (1), [Zn 2 (acdp)(μ-NO 3 )]•2H 2 O (2), and [Zn 2 (acdp)(μ-O 2 CCF 3 )]•2H 2 O (3) (Cl − = chloride; NO 3 − = nitrate; CF 3 CO 2 − = trifluoroacetate) of anthracene-affixed multifunctional organic assembly, H 3 acdp (H 3 acdp = N,N′-bis-[anthracene-2-ylmethyl]-N,N′-bis[carboxymethyl]-1,3-diaminopropan-2-ol), have emerged as promising antibacterial and antibiofilm agents in the domain of medicinal chemistry. Accordingly, complexes 1−3 were synthesized by utilizing H 3 acdp in combination with ZnCl 2 , Zn(NO 3 ) 2 •6H 2 O, and Zn(CF 3 CO 2 ) 2 •H 2 O respectively, in the presence of NaOH at ambient temperature.The complexation between H 3 acdp and Zn 2+ was delineated by a combined approach of spectrophotometric and spectrofluorometric titration studies. The stoichiometry of acdp 3− /Zn 2+ in all three complexes is observed to be 1:2, as confirmed by spectrophotometric/spectrofluorometric titration data. Elemental analysis (C, H, N, Zn), molar conductance, FTIR, UV−vis, and thermoanalytical (TGA/DTA) data were effectively used to characterize these complexes. Besides, the structures of 1−3 were established by density functional theory (DFT) calculation using B3LYP/6-311G, specifying a self-assembled compact geometry with average Zn•••Zn separation of 3.4629 Å. All three zinc complexes exhibited significantly high antibacterial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA BAA1717). However, complex 1 showed a more recognizable activity than 2 and 3, with minimum inhibitory concentration (MIC) values of 200, 350, and 450 μg/mL, respectively. The antimicrobial activity was tested by employing the minimum inhibitory concentration (MIC) and time-kill assay. The crystal violet (CV) assay and microscopic study were performed to examine the antibiofilm activity. As observed, complexes 1−3 had an effect on the production of extracellular polymeric substance (EPS), biofilm cell-viability, and other virulence factors such as staphyloxanthin and hemolysin production, autoaggregation ability, and microbial cell-surface hydrophobicity. Reactive oxygen species (ROS) generated due to inhibition of staphyloxanthin production in response to 1−3 were also analyzed. Moreover, complexes 1−3 showed an ability to damage the bacterial cell membrane due to accumulation of ROS resulting in DNA leakage. In addition, complexes 1−3 displayed a synergistic/additive activity with a commercially available antibiotic drug, vancomycin, with enhanced antibacterial activity. On the whole, our investigation disclosed that complex 1 could be a promising drug lead and attract much attention to medicinal chemists compared to 2 and 3 from therapeutic aspects.

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Section: Resultssupporting

confidence: 66%

Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus

Majumder

Sarkar

Das

et al. 2023

ACS Appl. Mater. Interfaces

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“…hyd./sol. 1.957 [11] 2.130 [9] 2.229 [5] n/a n/a n/a Tables S4 and S5 OH − 1.973 [7] 2.160 [2] 2.257 [1] 1.905 [5] 2.049 [20] 2.158 [4] Tables S1, S4 and S5 r M n+ 0.617 0.790 0.889 n/a n/a n/a 24 r M n+ Sh.…”

Section: Comparison With Other High-valent D 10 Metal Ionsmentioning

confidence: 99%

“…With the exception of the hexahydroxidostannate(IV) compounds, only one other, simple tin(IV) complex, a hexanitratostannate(IV), has been reported, with a mean Sn-O bond distance of 2.072 Å. 9 Also, five compounds with isolated tetrahedral tetraoxostannate(IV) ions, [SnO 4 ] 4− , with a mean Sn-O bond distance of 1.957 Å, are found in the literature, Table S1. †…”

Section: Introductionmentioning

confidence: 99%

On solvated tin(iv) ions and the coordination chemistry of high-valent d¹⁰ metal ions

Lundberg

Persson

2019

Dalton Trans.

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“…Pseudohalogen complexes of the type EY n q – are isolable for most p -block elements in groups 13–15: Y = N 3 (B–Tl, Si–Sn, P–Bi), NCS (P, Si–Sn), NCO (Si, Ge, Sn), NO 3 (B, Al, Si–Sn). In group 14, they take the form of EL 4 and EL 6 2– (E = Si–Pb, L = N 3 , NO 3 , NCO, NCS, NCSe). − However, there are only very few homoleptic cyanido complexes. This group of complexes is restricted to coordination centers of the less electronegative elements in groups 13 and 15 as P(CN) 3 , Ga(CN) 4 – , E(CN) 5 2– (E = In, Tl, Sb, Bi) and Bi(CN) 6 3– . − In group 14, the set of known complexes consist of the E(CN) 4 type (E = Ge, Sn), for which, apart from in situ 119 Sn NMR spectral data for the Cl/CN ligand exchange to form Sn(CN) 6 2– , little analytical data is available. − CN ligands possess a comparably low oxidation potential and this effects, for instance, the low thermal stability of P(CN) 5 which readily eliminates cyanogen at ambient temperature to form P(CN) 3 .…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Structures, and Infrared Spectra of the Hexa(cyanido) Complexes of Silicon, Germanium, and Tin

et al. 2019

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The rare octahedral EC6 coordination skeleton type is unknown for complexes with coordination centers consisting of Group 14 elements. Here, the first examples of such EC6 species, the hexacoordinate homoleptic cyanido complexes E(CN)6 2− , E = Si, Ge, Sn, have been synthesized from element halides SiCl4, GeCl4 and SnF4 and isolated as salts with PPN counter ions (PPN + = (Ph3P)2N + ) on a scale 0.2-1 g. Characterization by spectroscopic techniques and by structure determination through single crystal crystallographic methods show that these pseudohalogen complexes have effective octahedral symmetry in solution and in the solid state.Infrared spectra obtained in solution reveal that the T1u symmetric IR-active vibrations in all three complexes have unusually small oscillator strengths. The observed reluctance of Si(CN)6 2− , Ge(CN)6 2− and Sn(CN)6 2− to form from chloro-precursors was rationalized in terms of Gibbs free energies, which were found by ab initio calculations at the CCSD(T)-F12b/aug-cc-pVTZ(-PP)-F12 level of theory to be small or even positive. The work demonstrates that E(CN)6 2− complexes of silicon, germanium and tin are in fact stable at r.t. and exist as well-defined units in the presence of non-coordinating counter-ions. The results add to our understanding of the chemistry of pseudohalogens and structure and bonding.

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Homoleptic Poly(nitrato) Complexes of Group 14 Stable at Ambient Conditions

Abstract: Abstract. Using

Cited by 8 publications

References 42 publications

Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus

Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus

On solvated tin(iv) ions and the coordination chemistry of high-valent d¹⁰ metal ions

Syntheses, Structures, and Infrared Spectra of the Hexa(cyanido) Complexes of Silicon, Germanium, and Tin

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Homoleptic Poly(nitrato) Complexes of Group 14 Stable at Ambient Conditions

Abstract: Abstract. Using

Cited by 8 publications

References 42 publications

Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus

Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus

On solvated tin(iv) ions and the coordination chemistry of high-valent d10 metal ions

Syntheses, Structures, and Infrared Spectra of the Hexa(cyanido) Complexes of Silicon, Germanium, and Tin

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On solvated tin(iv) ions and the coordination chemistry of high-valent d¹⁰ metal ions