Homoisoflavanones from Disporopsis aspera

Nguyen, Anh Tho; Fontaine, Jeanine; Malonne, Hugues; Duez, Pierre

doi:10.1016/j.phytochem.2006.06.021

Cited by 54 publications

(29 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its molecular formula was determined as C 19 (Table 1) exhibited the typical proton signals for a \CH 2 \C\CH 2 \ moiety of 3-hydroxy-3-benzyl-4-chromanone with the H 2 -2 signal occurring at δ H 3.99 (d, J = 11.5 Hz) and 3.92 (d, J = 11.5 Hz) and the H 2 -9 signal occurring at δ H 2.82 (s). An ABX spin system was observed at δ H 6.81 (d, J = 8.5 Hz), 6.80 (d, J = 2.0 Hz) and 6.66 (dd, J = 8.5, 2.0 Hz).…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus

Zhang

Zeng

et al. 2012

Fitoterapia

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus

Zhang

Zeng

et al. 2012

Fitoterapia

View full text Add to dashboard Cite

“…This indicates the potential usefulness of 1 as a novel anti-cancer therapeutic. Nguyen et al reported significant cytotoxic activity of homoisoflavonoids [18], and Yen et al also described that homoisoflavonoids were efficient cytotoxic agents [20].…”

Section: Cytotoxic Activitiesmentioning

confidence: 99%

“…Feeding experiments showed that the biosynthesis of 3-benzylchroman-4-ones consists in modification of the C 6 AC 3 AC 6 chalcone/flavonoid pathway by insertion of an extra carbon atom [13]. These compounds were mainly discovered from plants belonging to the Liliaceae family and a few other plant species [14], and they were recorded to be responsible for biomedical activities of these plants, such as antioxidant activity [15][16][17], cytotoxic activity [18][19][20], inhibition of platelet aggregation [21], cough relief [22], hyperglycemia [23], anti-fungal [12], anti-inflammatory, anti-allergic, antihistaminic and angioprotective activities. They have been also detected as potent phosphodiesterase inhibitors [11,24,25].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Ghoran

Saeidnia

Babaei

et al. 2014

Bioorganic Chemistry

View full text Add to dashboard Cite

“…This plant has been widely used for curing chronic cough and cancer in China [7]. The volatile compositions of Disporopsis pernyi have been previously characterized, but its effective components have seldom been reported [8].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cytotoxicity and the Chemical Composition in Disporopsis pernyi and its Confused Variety

Lin¹

2017

FSN

View full text Add to dashboard Cite

This study aimed to investigate the cytotoxic properties of the extracts and chemical compositions of the three herbs. Materials and Methods Plant materialFresh Disporopsis pernyi were collected from an alpine site in August 2015. The site was located in the Guizhou province (longitude: 106°95'-106°98'E, latitude: 26°44'-26°47'N; altitude: 1200-1800m). Polygonatum odoratum (90226) and Panax japonicus (90149) were purchased from Pengxiang Pharmaceuticals Co., Ltd. The origins of them were showed in table 1. The air-dried plant material was pulverized, screened through 40-mesh sieves, and stored in the refrigerator. Chemicals and reagentsMethanol, petroleum ether, ethanol, ethyl acetate, anhydrous sodium sulphate and ferrous sulphate (analytical grade) were purchased from Tianjin Damao Chemical Reagent Co., Ltd. (Tianjin, China). Purified water was purchased from Hangzhou Wa ha ha Co. Ltd. (Hangzhou, China) n-Alkanes (9-35) were purchased from Aladdin Chemical Reagent Co. Ltd. (Shanghai, China). AbstractThe natural plant Disporopsis pernyi has been widely used as folk medicine for the treatment of chronic cough, cancer and other conditions in China. But we didn't know exactly what the active ingredients are. Disporopsis pernyi is often confused with Polygonatum odoratum and Panax japonicus. This study aimed to investigate the cytotoxic properties and chemical compositions of the three herbs. Eight pure compounds, which were identified as Stearic acid, Palmitic acid, β-Daucosterol, Luteolin, Rutin, Salicylic acid, Betulinic acid and Betulin were obtained and characterized from Disporopsis pernyi by column chromatography followed by IR, MS, 1H NMR and 13C NMR. The cytotoxic activities of the compounds and 4 fractions were tested against human breast cancer cell line MCF-7. The results suggested that the ethyl acetate fraction of Disporopsis pernyi had cytotoxic activity. Betulinic acid and Betulin contributed significantly to the cytotoxic activity of the extract. However, the extractions of Polygonatum odoratum and Panax japonicus did not have cytotoxic activity. Petroleum ether fractions from both Polygonatum odoratum and Panax japonicus were subjected to gas chromatography-mass spectrometry analysis, 9 and 16 species were identified, respectively. As a result, the three herbs were determined to be different from each other in terms of their volatile chemical constituents.

show abstract

Homoisoflavanones from Disporopsis aspera

Cited by 54 publications

References 12 publications

Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus

Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus

Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Comparison of Cytotoxicity and the Chemical Composition in Disporopsis pernyi and its Confused Variety

Contact Info

Product

Resources

About