Homograft (Allograft) Tympanoplasty Update

Sg, Lesinski

doi:10.1002/lary.1986.96.11.1211

Cited by 8 publications

(2 citation statements)

References 13 publications

(3 reference statements)

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“…With allograft incus transposition in M-S+ defect, we got satisfactory result in 50% (2 cases). Bahadur et a1 [4] had a-b gap closure to 15 dB or less in 60% (6 cases) and Lesinski [5] had in 80% (47 cases). Intragroup comparison between autograft and allograft ossicles shows satisfactory results in 80% and 60% respectively.…”

Section: Discussionmentioning

confidence: 99%

Middle Ear Reconstruction – Our Experience

1994

Medical Journal Armed Forces India

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A comparative study of ossicular reconstrution using four different graft material was carried out on 40 patients as a second stage procedure from July 1989 to June 1991. The grart materials used were: autologus ossicular bone graft. allogeneic ossicular bone graft, autologus cartilage and bio-compatible materials. All patients were observed for a period ranging from one to two years. Extrusion of ossicular graft was prevented by use of a lace of cartilage between the ossicular graft and neotympanic membranes.Satisfactory results were obtained with cartilage graft in 6%.allogeneic ossicles 70%. autologus ossicular graft 80% and bio-compatible materials 33.3%.

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Section: Discussionmentioning

confidence: 99%

Middle Ear Reconstruction – Our Experience

1994

Medical Journal Armed Forces India

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“…In the late 1960s, the development of tympano‐ossicular homograft procedures produced major progress in reconstructive surgery of the middle ear 1,2 . Numerous studies were published that demonstrated the outstanding results obtained with this new surgical approach 2‐10 . However, the spread of the human immunodeficiency virus (HIV) epidemic during the 1980s produced a major setback in the use of homografts.…”

Section: Introductionmentioning

confidence: 99%

Risk of Transmission of Human Immunodeficiency Virus Infection During Tympano‐ossicular Homograft: An Experimental Study

et al. 1996

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It is generally agreed that middle ear reconstructive surgery performed with tympano-ossicular homografts produces superior functional results compared with prosthetic material, especially with respect to extrusion rate. The use of homografts, though, has been seriously hampered recently by the fear of transmission of human immunodeficiency virus (HIV) infection. In HIV-infected patients, the virus is primarily found in the cells of the lymphoid and monocytic lineage. The nature of the tissues in the eardrum and ossicles, mostly fibrous tissue and compact bone without marrow, suggests that little virus load should be found in homografts. Indeed, culturing minced homograft tissue from two HIV-infected donors with acquired immune deficiency syndrome (AIDS) in a sensitive culture system with PHA-stimulated lymphoblasts produced no virus. Before use, homografts undergo a fixation procedure in 5% formaldehyde and then are kept in a solution containing Cialit as a preservative. The authors therefore examined the capacity of formaldehyde and Cialit to reduce the infectivity of HIV in models of infected tissue as measured in vitro. The reduction of in vitro infectivity due to these treatments was at least 10(5)-fold and 10(2)-fold, respectively. Coupled with the low virus burden in tympano-ossicular tissue, our data suggests that the fixation procedure affords such a reduction in infectivity that the risk of HIV transmission, even from an HIV-infected donor, is vanishingly low.

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