Internal medicine plays a critical role in the curriculum system of traditional Chinese medicine (TCM) universities, which is the main course in TCM colleges and the professional knowledge must be mastered by medical students. However, due to the immense contents and concepts in internal medicine, the traditional lecture-based learning (LBL) led to dissatisfactory education effects. The purpose of the study is to explore the application of hybrid case-based learning (CBL) + team-based learning (TBL) method in educational practice of internal medicine in TCM universities. The undergraduates majoring in Chinese medicine of grade 2014, 2015 and 2016 from Beijing University of Chinese Medicine (BUCM) were enrolled. Students of grade 2014 were utilized as the control group, adopting traditional teaching method. Students of grade 2015 and 2016 were employed as the experimental groups, using the hybrid CBL+TBL teaching method. At the end of the internal medicine curriculum, the teaching resultant was evaluated by both theoretical test and skill assessment. The results demonstrated that experimental groups scored better than control group in both theory and clinical examinations, and the discrepancies were significant, respectively. The introduction of hybrid CBL+TBL teaching method into education of internal medicine in TCM universities promoted students' ability of self-learning and sense of teamwork, so as improved the teaching effectiveness of clinical courses.