Homogeneous Pt nanostructures surface functionalized with phenylboronic acid phosphonic acid derivatives as potential biochemical nanosensors and drugs: SERS and TERS studies

Abstract

Here, surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS) were used to characterize the selective adsorption of N-substituted 4-[(NH-R) (phosphono)-S-methyl]phenylboronic acids on the surface of platinum nanoparticles (PtNPs) from an aqueous solution and from air. The nature of the interaction of the studied compounds with the PtNPs/H 2 O and PtNPs/air interfaces was discussed and compared. For this purpose, 4-[(N-anilino)(phosphono)-S-methyl]phenylboronic acid (1-PBA-PA) and its two analogs (2-PBA-PA and bis{1-PBA-PA}) as well as the PtNPs were synthesized in surfactant/ion-free solution via a synthetic route that allows control of the size and morphology of the NPs. The positively charged PtNPs with a size of $12 nm were characterized by ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), scanning electron microscopy (SEM), and X-ray powder diffraction (XRD).phenylboronic acid phosphonic acid (PBA-PA), platinum nanoparticles (PtNPs), surfaceenhanced Raman scattering (SERS), tip-enhanced Raman scattering (TERS) | INTRODUCTIONPlatinum-based (Pt) drugs are widely used to treat human cancers. [1][2][3] However, their clinical use is limited by side effects such as lack of selectivity, drug resistance, cytopenias, asthenia, anaphylaxis, and high systemic toxicity (ototoxicity, hepatotoxicity, and cardiotoxicity), as well as congenital or acquired treatment resistance. 4,5 Therefore, great efforts have been put into the search for new platinum compounds (hindered, trans-configured, or multinuclear complexes, monofunctional platinum drugs, complexes with biologically active ligands, and platinum(IV) prodrugs) with anticancer properties, but they have not found clinical application. 6-10 However, thanks to the advances in nanotechnology and the great interest in the use of metallic nanoparticles (NPs) in the development and design of highly sensitive and specific biochemical nanosensors and drugs, PtNP-based systems show promise for cancer therapies (photodynamic, chemodynamic, photothermal, radiosensitizing, etc.). [11][12][13] PtNPs on whose surface an agent with antitumor activity has been immobilized may exhibit higher catalytic efficiency in destroying cancer cells than pure PtNPs. 12 Phosphonic acids of phenylboronic acid (PBA) and its derivatives are a promising class of candidates for inhibiting actively migrating tumor cells without affecting normal cells (e.g., human prostate and breast cancer), 14 activating pyruvate kinase M2 (PKM2), which is critical for tumorigenesis, 15 inhibiting arginase to enhance anti-tumor immune responses, 16 etc. PBA is a boronic acid (BA) with a phenyl ring and two hydroxyl groups attached to the sp 2

Plant-Assisted Green Synthesis of MgO Nanoparticles as a Sustainable Material for Bone Regeneration: Spectroscopic Properties

“…Surface-enhanced Raman scattering (SERS) is a highly sensitive, selective, and relatively fast technique that provides information about surface reactions, interfacial charge transfer, and the architecture of the surface-bound molecule-metal complex. It is used for chemical and biological sensing by enhancing the cross-section of Raman scattering from molecules adsorbed on or near the surface of nanostructured materials [61,62]. The enhancement is achieved by plasmon-mediated electric field enhancement or by chemical enhancement [63].…”

Synthesis Methods and Optical Sensing Applications of Plasmonic Metal Nanoparticles Made from Rhodium, Platinum, Gold, or Silver

“…Pang et al used Ag@Pt NPs as an enzymatic reporter to identify microcystin-leucine arginine antibodies [99]. Proniewicz et al used SERS and tip-enhanced Raman scattering (TERS) to characterize the selective adsorption of phenylboronic acid phosphonic acid (PBA-PA) derivatives on the surface of PtNPs from an aqueous solution and from air [100]. Lin et al presented a SERS-based nanoprobe (Au@Pt core-shell NPs) for direct and simultaneous identification of multiple mitochondrial reactive oxygen species by their distinct Raman fingerprints without introduction of Raman reporters [101].…”