Homogeneous preparation of water-soluble products from chitin under alkaline conditions and their cell proliferation in vitro

Xie, Qinyue; Yang, Jianhong; Shen, Fengqin; Gu, Jianbin

doi:10.1016/j.ijbiomac.2023.123321

Cited by 3 publications

(1 citation statement)

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“…Chitin deacetylation in an alkaline medium occurs either in a heterogeneous [ 7 ] or homogeneous medium [ 48 ]. Usually, according to the heterogeneous method, chitin is treated with a concentrated NaOH solution at a high temperature for several hours.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Heterogeneous Alkaline Deacetylation of Chitin: A Review

et al. 2023

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This review provides an analysis of experimental results on the study of alkaline heterogeneous deacetylation of chitin obtained by the authors and also published in the literature. A detailed analysis of the reaction kinetics was carried out considering the influence of numerous factors: reaction reversibility, crystallinity and porosity of chitin, changes in chitin morphology during washing, alkali concentration, diffusion of hydroxide ions, and hydration of reacting particles. A mechanism for the chitin deacetylation reaction is proposed, taking into account its kinetic features in which the decisive role is assigned to the effects of hydration. It has been shown that the rate of chitin deacetylation increases with a decrease in the degree of hydration of hydroxide ions in a concentrated alkali solution. When the alkali concentration is less than the limit of complete hydration, the reaction practically does not occur. Hypotheses have been put forward to explain the decrease in the rate of the reaction in the second flat portion of the kinetic curve. The first hypothesis is the formation of “free” water, leading to the hydration of chitin molecules and a decrease in the reaction rate. The second hypothesis postulates the formation of a stable amide anion of chitosan, which prevents the nucleophilic attack of the chitin macromolecule by hydroxide ions.

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Section: Introductionmentioning

confidence: 99%