Homogeneous magnetic fields influence pancreatic islet function in vitro

Hayek, Alberto; Guardian, Carmela M.; Guardian, Julian; Obarski, Gregory E.

doi:10.1016/0006-291x(84)90458-3

Cited by 19 publications

(4 citation statements)

References 7 publications

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“…This result is supported by previous data (Hayek et al 1984;Sakurai et al 2005;Chater et al 2006a). Miyakoshi et al (2006) using a system for exposure of cultured cell (ELF 60 Hz, 5 mT, 1 h), showed also a significant decrease in insulin release.…”

Section: Discussionsupporting

confidence: 92%

Time-dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat

Lahbib¹,

Elferchichi²,

Ghodbane³

et al. 2010

gpb

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Abstract. In the following study, we investigate the effects of static magnetic field (SMF) (128 mT, 1 h/day during 5 or 15 consecutive days) on anthropometric parameters, glucose and lipid metabolism in rats. Exposure to SMF during 5 days induced a decrease (-8%, p < 0.05) in relative liver weight and serum insulin concentration (-56%, p < 0.001), while blood glucose level was increased (+10%, p < 0.001). By contrast, the same treatment failed to alter body weight, relative kidney weight and levels of lactate, cholesterol, triglycerides and phospholipids. Exposure to SMF during 15 days induced a decrease (-15 %, p < 0.001) in body weight, liver weight (-15 %, p < 0.05), insulin concentration (-63%, p < 0.001), plasmatic lactate level (-55%, p < 0.05) and increased glucose (+24%, p < 0.001), cholesterol (+30%, p < 0.01,) and phospholipids levels (+58%, p < 0.001), whereas, triglycerides decreased (-28%, p < 0.001). These results showed that SMF effects on glucose and lipid metabolism are time-dependent.

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Section: Discussionsupporting

confidence: 92%

Time-dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat

Lahbib¹,

Elferchichi²,

Ghodbane³

et al. 2010

gpb

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“…26 Studies in several cohorts with varied baseline vitamin D status have reported an association between vitamin D deficiency and impaired glucose-mediated insulin release. [14][15][16][17][18][19][20][21][22][23][24][25][26][27] Vitamin D supplementation improved insulin release [14][15][16][17][18][19][20][21][22][23][24][25][26][27] in some small-scale short-term randomized trials. Vitamin D may have a beneficial effect on insulin action directly, by stimulating the expression of insulin receptor and thereby enhancing hormone responsiveness for glucose transport.…”

Section: Commentmentioning

confidence: 99%

Vitamin D Supplementation Ameliorates Hypoinsulinemia and Hyperglycemia in Static Magnetic Field–Exposed Rat

Lahbib¹,

Ghodbane²,

Maâroufi³

et al. 2013

Archives of Environmental & Occupational Health

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The purpose of this study is to evaluate the effects of vitamin D supplementation on glucose and lipid metabolism in static magnetic field (SMF)-exposed rats. Rats exposed to SMF (128 mT; 1 h/day) during 5 consecutive days showed an increase in plasma glucose level and a decrease in plasma insulin concentration. By contrast, the same treatment failed to alter body weight and plasmatic total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglyceride levels. Interestingly, supplementation with vitamin D (1,600 IU/100 g, per os) corrected and restored glycemia and insulinemia in SMF-exposed rats. The same treatment had no effects on lipid metabolism.

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“…Previously, Joelly et al [1983] reported that calcium ion content, calcium ion efflux, and insulin secretion during glucose stimulation were reduced when isolated rabbit islets were exposed to low frequency pulsed magnetic fields. Hayek et al [1984] reported that exposure to low intensity homogeneous magnetic fields inhibited insulin release from isolated newborn rat islets stimulated by high glucose concentration (16.7 mM) and aminophylline (10 mM). Recently, Laitl-Kobierska et al [2002] reported that long term exposure of rats to ELFMF led to increased synthesis and secretion of insulin.…”

Section: Introductionmentioning

confidence: 99%

An extremely low frequency magnetic field attenuates insulin secretion from the insulinoma cell line, RIN‐m

Sakurai

Satake

Sumi

et al. 2004

Bioelectromagnetics

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In this study, we investigated the effects of exposure to an extremely low frequency magnetic field (ELFMF) on hormone secretion from an islet derived insulinoma cell line, RIN-m. We stimulated RIN-m cells to secrete insulin under exposure to an ELFMF, using our established system for the exposure of cultured cells to an ELFMF at 5 mT and 60 Hz, or under sham exposure conditions for 1 h and observed the effects. In the presence of a depolarizing concentration of potassium (45 mM KCl), exposure to ELFMF significantly attenuated insulin release from RIN-m cells, compared to sham exposed cells. Treatment with nifedipine reduced the difference in insulin secretion between cells exposed to an ELFMF and sham exposed cells. The expression of mRNA encoding synaptosomal associated protein of 25 kDa (SNAP-25) and synaptotagmin 1, which play a role in exocytosis in hormone secretion and influx of calcium ions, decreased with exposure to an ELFMF in the presence of 45 mM KCl. These results suggest that exposure to ELFMF attenuates insulin secretion from RIN-m cells by affecting calcium influx through calcium channels.

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Homogeneous magnetic fields influence pancreatic islet function in vitro

Cited by 19 publications

References 7 publications

Time-dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat

Time-dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat

Vitamin D Supplementation Ameliorates Hypoinsulinemia and Hyperglycemia in Static Magnetic Field–Exposed Rat

An extremely low frequency magnetic field attenuates insulin secretion from the insulinoma cell line, RIN‐m

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