Homogeneous Liquid–Liquid Microextraction of Organic Compounds

Дмитриенко, С. Г.; Apyari, V. V.; Gorbunova, M. V.; Tolmacheva, V. V.; Zolotov, Yu. A.

doi:10.1134/s1061934820110052

Cited by 32 publications

(11 citation statements)

References 143 publications

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“…In other words, an ACN/water-based “in situ LLE” can be well realized through a simple cooling down process. In the past few years, this mechanism (naming as “cold-induced phase separation (CIPS),” “low-temperature-induced phase separation,” “homogeneous liquid-liquid microextraction,” “low-temperature partition,” and others) has been mainly utilized for drug/pesticide-residue analysis in food/environmental science ( 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ). However, its applicability for pretreatment of biotargets remains to be clarified.…”

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confidence: 99%

Cold-induced phase separation for the simple and reliable extraction of sex hormones for subsequent LC-MS/MS analysis

Peng

Yang

et al. 2022

Journal of Lipid Research

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confidence: 99%

Cold-induced phase separation for the simple and reliable extraction of sex hormones for subsequent LC-MS/MS analysis

Peng

Yang

et al. 2022

Journal of Lipid Research

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“…In these cases, HLLE with the addition of a small amount of a hydrophobic solvent (chloroform or hexane) to a homogeneous water- methanol solution is commonly used. The technique of homogeneous liquid-liquid microextraction and a detailed description of its modifications were considered in a review by Dmitrienko et al [60].…”

Section: Homogeneous Liquid-liquid Extractionmentioning

confidence: 99%

Possibilities and Limitations of Solid-Phase and Liquid Extraction for the Determination of Polycyclic Aromatic Hydrocarbons in Environmental Samples

et al. 2021

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The review systematizes data on various extraction techniques for sample preparation in the determination of polycyclic aromatic hydrocarbons (PAHs) in environmental samples, provides a classification, and describes the capabilities of these techniques. The main versions and methods of solid-phase extraction (SPE) and liquid-liquid (LLE) extraction of structurally different PAHs from complex multicomponent systems are discussed. The variety of SPE and LLE methods, the peculiarities of their combinations with other methods, and the advantages and disadvantages of each sample preparation method are demonstrated. Chromatographic methods are preferred for detection after the solid-phase or liquid-liquid extraction of PAHs from environmental samples.

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“…HLLME typically utilizes small volumes of hydrophilic solvents as extractants that are miscible with water [21]. Due to the infinitely large surface area among the different phases, increased accessibility of this solvent to the target analytes can be achieved, resulting in a high extraction efficiency, high mass and rapid equilibrium [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the infinitely large surface area among the different phases, increased accessibility of this solvent to the target analytes can be achieved, resulting in a high extraction efficiency, high mass and rapid equilibrium [22,23]. Moreover, HLLME overcomes the need for analyte back-extraction due to the compatibility of the solvent with most chromatographic systems [21]. Common types of HLLME include the saltinduced HLLME (SI-HLLME) [24] and the sugar-induced HLLME [25], in which phase separation is achieved by the addition of salts and sugars, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Common types of HLLME include the saltinduced HLLME (SI-HLLME) [24] and the sugar-induced HLLME [25], in which phase separation is achieved by the addition of salts and sugars, respectively. Other paths for the induction of the formation of the extractant phase include the reduction in temperature, the introduction of small amounts of hydrophobic solvents, the addition of buffer solutions for the acidification of the sample solution and the introduction of aprotic solvents [21,23]. Due to its inherent benefits, SI-HLLME has established itself as a useful bioanalytical tool.…”

Section: Introductionmentioning

confidence: 99%

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Salt-Induced Homogeneous Liquid–Liquid Microextraction of Piroxicam and Meloxicam from Human Urine Prior to Their Determination by HPLC-DAD

2022

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A salt-induced homogeneous liquid–liquid microextraction (SI-HLLME) protocol combined with high-performance liquid chromatography–diode array detection is presented for the first time for the determination of piroxicam and meloxicam in human urine. The main parameters affecting the performance of the sample preparation protocol were optimized by means of a two-step experimental design (i.e., 2-level fractional factorial design and Box–Behnken design). Following its optimization, the proposed method was thoroughly validated in terms of the total error concept in order to take into consideration the random and systematic errors. For the target analytes, accuracy profiles were constructed, and they were used as graphical decision-making tools. In all cases, the β-expectation tolerance intervals complied with the acceptance criteria of ±15%, proving that 95% of future results will fall within the defined bias limits. The limits of detection were 0.02 μg mL−1 and 0.03 μg mL−1 for piroxicam and meloxicam, respectively. The relative standard deviations were lower than 4.4% in all cases, and the mean relative biases ranged between −5.7 and 3.4% for both drugs. The proposed scheme is simple and rapid, while it is characterized by high sample throughput. Moreover, SI-HLLME requires reduced sample and reagent consumption, according to the requirements of Green Analytical Chemistry.

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Homogeneous Liquid–Liquid Microextraction of Organic Compounds

Cited by 32 publications

References 143 publications

Cold-induced phase separation for the simple and reliable extraction of sex hormones for subsequent LC-MS/MS analysis

Cold-induced phase separation for the simple and reliable extraction of sex hormones for subsequent LC-MS/MS analysis

Possibilities and Limitations of Solid-Phase and Liquid Extraction for the Determination of Polycyclic Aromatic Hydrocarbons in Environmental Samples

Salt-Induced Homogeneous Liquid–Liquid Microextraction of Piroxicam and Meloxicam from Human Urine Prior to Their Determination by HPLC-DAD

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