Partial molar volume [Formula: see text] partial molar compressibility [Formula: see text] Jones–Dole viscosity B coefficient, and solute activation parameters of adenosine in water–DMSO mixtures in the presence of Ca2+ and K+ ions have been calculated from ultrasonic, volumetric, and viscometric studies at 25, 30, 35, and 40 °C(± 0.01° C). The results are discussed in terms of the Jones–Dole viscosity B coefficients and the transition state parameters for viscous flow.