Homogeneous continuous-flow nitration of O-methylisouronium sulfate and its optimization by kinetic modeling
Jiapeng Guo,
Weike Su,
An Su
Abstract:Nitration of O-methylisouronium sulfate under mixed acid conditions gives O-methyl-N-nitroisourea, a key intermediate of neonicotinoid insecticides with high application value. The reaction is a fast and highly exothermic process with a high mass transfer resistance, making its control difficult and risky. In this paper, a homogeneous continuous-flow microreactor system was developed for the nitration of O-methylisouronium sulfate under high concentrations of mixed acids, with a homemade static mixer eliminati… Show more
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