Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

Tong, Yingpeng; Jiang, Yu; Guo, Dan; Yan, Yongqiu; Jiang, Shanqun; Lu, Yu; Bathaie, S. Zahra; Wang, Ping

doi:10.1155/2018/9649062

Cited by 10 publications

(5 citation statements)

References 16 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems that saffron and its major ingredients may have a pleiotropic mechanism of action against malignant cells. There are a plethora of studies that have analyzed the effect and the action mechanism of the different ingredients of saffron extract and how their action could be optimized [ 13 , 14 ]; of great interest is also the fact that saffron’s major ingredients may act synergistically against malignant cells [ 15 ], suggesting that saffron extract may be more effective than its components alone. We need to note though that apart from the unique compounds that can be found only in saffron extracts, as already mentioned above, saffron possesses a plethora of other bioactive compounds, such as kaempferol and its glycosides, other flavonols such as quercetin, etc.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

et al. 2020

View full text Add to dashboard Cite

Cancer is the second leading cause of death globally with an estimated 9.6 million deaths in 2018 and a sustained rise in its incidence in both developing and developed countries. According to the WHO, about 1 in 6 deaths is due to cancer. Despite the emergence of many pioneer therapeutic options for patients with cancer, their efficacy is still time-limited and noncurative. Thus, continuous intensive screening for superior and safer drugs is still ongoing and has resulted in the detection of the anticancer properties of several phytochemicals. Among the spices, Crocus sativus L. (saffron) and its main constituents, crocin, crocetin, and safranal, have attracted the interest of the scientific community. Pharmacological experiments have established numerous beneficial properties for this brilliant reddish-orange dye derived from the flowers of a humble crocus family species. Studies in cultured human malignant cell lines and animal models have demonstrated the cancer prevention and antitumor activities of saffron and its main ingredients. This review provides an insight into the advances in research on the anticancer properties of saffron and its components, discussing preclinical data, clinical trials, and patents aiming to improve the pharmacological properties of saffron and its major ingredients.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Saffron is an important, delicate spice with a flavor and golden color and smell like sea air. It is used in cooking, medicine, cosmetics, perfumery, dye and clothes [4][5][6]. The chemical components of saffron extract showed that it has four main active ingredients namely safranal, crocin, picrocrocin and crocetin.…”

Section: Introductionmentioning

confidence: 99%

Effect of Crocin on the Spermatogenesis Indices of Mice Testis: A Histopathological and Histomorphological Study

Mohammadpour

Al-Fartwsy

Parham

2023

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

C ROCIN, the chief component of Crocus Sativus L. (Saffron), is well recognized for its antioxidant action by scavenging reactive oxygen species (ROS), particularly superoxide anion. In this research, 32 adult NMRI male mice were divided into four groups; control and the three experimental groups as crocin at 4, 20, and 100 mg/kg, and all doses were given to mice by gavage for six weeks. For histological study, tissue sections were stained by hematoxylin and eosin (H&E) and Masson's trichrome stains. The spermatogenesis indices include the repopulation index (RI), spermatogenesis index (SI), tubular differentiation index (TDI), and Sertoli cell index (SEI) were measured. Data was evaluated by one-way ANOVA, using SPSS software. The results of this study showed that crocin (100 mg/kg) significantly reduced the diameter of seminiferous tubules and the number of sperm in seminiferous tubules. The statistical analysis for TDI and SI in experimental groups presented that there was no significant difference in various doses of crocin, compared with the control group while, RI Data analysis showed that all administrated doses of crocin cleared significance to reduce it, compared with the control group. Also, the number of Sertoli cells significantly reduced in all treated groups with crocin.We concluded that crocin at the high dose of 100 mg/kg has some side effects on the reproductive system of mice while is relatively safer at doses of 4 and 20 mg/kg. Therefore, lower doses are suggested for further studies and possible clinical trials.

show abstract

“…Ethanol of 70 and 80% was selected as the best extraction solvent for total crocin extraction from saffron [9]. However, crocin is an unstable compound under thermal process, which dramatically degrades at temperatures above 70 • C [10,11] The goal of extracting crocin from gardenia is for use as an additive in food processing.…”

Section: Introductionmentioning

confidence: 99%

Extraction Optimization of Crocin from Gardenia (Gardenia jasminoides Ellis)Fruits Using Response Surface Methodology and Quality Evaluation of Foam-Mat Dried Powder

et al. 2022

View full text Add to dashboard Cite

The crocin in gardenia, as a medical plant, has drawnthe attention of researchers and scientists due to its color and high antioxidant activity. To optimize the extraction parameters of crocin from gardenia fruits, response surface methodology (RSM) was employed.The effects of four independent variables, namely extraction temperature (45–55 °C), time (40–60 min), percentage of gardenia fruits(15–25%), and ethanol concentration (50–60%),on a crocin compound were investigated. The extract from the gardenia fruit was dried at different temperatures (55–70 °C) by the foam-mat drying method. The optimal extraction parameters were an extraction temperature of 55 °C, time of 57 min, percent of fruits in solvent at 24%, and an ethanol concentration of 56%. The results showed that the dried gardenia powder had maintained the crocin content well(6.64 mg/g), and the product with low water activity and moisture content of 0.33 and 5.72%, respectively, is suitable for storage. The foam-mat dried product also maintains the natural color and characteristics inherent in the raw materials, which could also be used as supplemental ingredients for other food industries.

show abstract

Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

Cited by 10 publications

References 16 publications

Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

Effect of Crocin on the Spermatogenesis Indices of Mice Testis: A Histopathological and Histomorphological Study

Extraction Optimization of Crocin from Gardenia (Gardenia jasminoides Ellis)Fruits Using Response Surface Methodology and Quality Evaluation of Foam-Mat Dried Powder

Contact Info

Product

Resources

About