Homoeopathic Viscum album (10-3) is More Cytotoxic to in vitro Culture of Human Breast Cancer Cell Line than to Human Mesenchymal Stem Cells

Valle, Ana Catarina Viana; Aguiar, Lana Ribeiro; Brunel, Hilana dos Santos Sena; Malard, Patricia Furtado; Villaroel, Carla Lujan; Andrade, Rosângela Vieira de

doi:10.51910/ijhdr.v19i4.1036

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Furthermore, veterinary medicine and/or homeopathy are the most promising fields for future applications [ 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 ], not excluding the antiviral properties, which ask for further continuous attention [ 262 ]. Therefore, the knowledge about European mistletoe properties is in continuous evolution and requires a continuous revision of its use in evidence-based complementary and alternative medicine [ 263 , 264 , 265 , 266 ].…”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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The therapeutic story of European mistletoe (Viscum album L.) presents a seesawing profile. In ancient times, this hemiparasitic plant was considered a panacea and even to be endowed with exceptional beneficial properties. In more recent times, despite its multiple uses in traditional medicines, some parts of the plant, in particular the berries, were considered poisonous and dangerous, including concerns of cytotoxicity, which spread serious suspicion on its medicinal utility. However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. In Central Europe, the hydro-alcoholic extracts of European mistletoe register a relevant and continuous utilization in anthroposophic medicine, which is a holistic system that includes the utilization of phytomedicinal substances. In Switzerland and Germany, most physicians and patients use these products as complementary therapy in oncological treatments. However, despite its increasing use in this field, the results of mistletoe’s use are not always convincing, and other aspects have appeared. Nowadays, products that contain mistletoe are utilized in several fields, including diet, phytotherapy, veterinary medicine and homeopathy, but in particular in cancer therapies as coadjuvant factors, in consideration of several positive effects including effects in the improvement of quality-of-life conditions and reinforcement of the immune system. In this review, based on the understanding of the association between cancer and inflammation, we propose a relationship between these recent uses of mistletoe, based on its antioxidant properties, which are supported by phytochemical and pharmacological data. The unicity of mistletoe metabolism, which is a direct consequence of its hemiparasitism, is utilized as a key interpretation element to explain its biological properties and steer its consequent therapeutic uses.

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Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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Anticancer potential of homeopathic medicines: an updated review

Manivannan,

Veeraraghavan,

Manoharan

et al. 2023

Natural Product Research

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Resveratrol and Viscum album anticancer effect in canine mammary tumor cell lines

Vaz,

Lainetti,

Leis

et al. 2024

BJVP

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Mammary gland tumors are the most common neoplasms in female intact dogs and share some biological and histopathological aspects with those in women with breast cancer, making them a good model in comparative oncology. Resveratrol is a polyphenol found in several plants, and some studies have indicated that it acts in the neoplastic process as an anticancer drug. Viscum album is a hemiparasitic plant widely used as an adjuvant treatment for cancer in some countries. Thus, this study aimed to evaluate the antitumor potential of resveratrol and homeopathic Viscum album together and separately using two previously characterized canine mammary tumor cell lines (UNESP-CM9 and UNESP-CM60). The cell viability test (MTT) was performed, which revealed an IC50 of 3.11 μl/100 ml for UNESP-CM9 and 2.993 μl/100 ml for UNESP-CM60 for Viscum album, and for resveratrol, the IC50 was 281.6 μM for UNESP-CM9 and 105.5 μM for UNESP-CM60. The combination of both natural compounds led to tumor cell death at a lower IC50. The cell migration assay demonstrated an increase in cell migration time with both treatments. UNESP-CM9 closed 35.66% of the wounds in the control group and 15.51% of the wounds in the viscum group, while UNESP-CM60 closed 39.46% of the wounds in the control group and 19.95% of the wounds in the viscum group and 2.41% of the wounds in the resveratrol group. Thus, these two compounds have antitumor potential, making them possible alternatives to conventional treatments.

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Homoeopathic Viscum album (10-3) is More Cytotoxic to in vitro Culture of Human Breast Cancer Cell Line than to Human Mesenchymal Stem Cells

Cited by 3 publications

References 21 publications

The Anti-Inflammatory Activity of Viscum album

The Anti-Inflammatory Activity of Viscum album

Anticancer potential of homeopathic medicines: an updated review

Resveratrol and Viscum album anticancer effect in canine mammary tumor cell lines

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