Homocysteine, vitamin B12 and folate levels in premature coronary artery disease

Sadeghian, Saeed; Fallahi, Faramarz; Salarifar, Mojtaba; Davoodi, Gholamreza; Mahmoodian, Mehran; Fallah, Nader; Darvish, Soodabeh; Karimi, Abbasali

doi:10.1186/1471-2261-6-38

Cited by 79 publications

(70 citation statements)

References 36 publications

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“…Furthermore, plasma Hcy levels were associated with arterial stiffness only in males [35]. Circulating Hcy levels were also significantly higher in males with CHD than in males without CHD, whereas no difference was observed in Hcy levels in females with regard to CHD [36]. As for lipid profiles, TG and HDL-C seem to be better predictors of CHD risk than TC or LDL-C in females [15].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Association of homocysteine-metabolizing enzyme gene polymorphisms and lipid profiles: an investigation of a geneenvironment interaction

Jiang¹,

Venners²,

Hsu³

et al. 2018

Oncotarget

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The interaction term for the MTHFR 677TT genotype and gender was also significant for TC and LDL-C levels (P = 0.0147 and 0.0243 for interaction, respectively). Further haplotype analysis showed that there also were significant interactions between gender and hap2 (MTHFR 677C/1298A) on TC (P = 0.009) and LDL-C (P = 0.013). We suggest that the negative effects of the MTR and MTHFR genotypes on serum lipids are based on certain gene-environment interactions in the Chinese general population.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Association of homocysteine-metabolizing enzyme gene polymorphisms and lipid profiles: an investigation of a geneenvironment interaction

Jiang¹,

Venners²,

Hsu³

et al. 2018

Oncotarget

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“…Kawashiri et al 13 reported that plasma homocysteine level of subjects in younger IHD group was significantly higher than that of subjects in older IHD group. Sadeghian et al 14 concluded that hyperhomocysteinemia is an independent risk factor for CAD in young especially in men.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Different Risk Factors and Coronary Angiographic Profile in Younger and Older Patients with Ischeamic Heart Disease

Islam

Chowdhury

Khandaker³

et al. 2015

Cardiovasc. j.

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Background: Due to socio-economic improvement and changes in the life style, ischeamic heart disease is becoming a major burden to our health care system. In recent years, the incidence is increasing among younger age groups as well.Methods: A total of 120 patients with ischeamic heart disease admitted for coronary angiogram were included in the study and were divided into two groups. Among them, 60 younger patients were in Group-I (d 40 years of age); 60 older patients in Group-II (>40 years of age). We compared demographic profiles, different risk factors and angiographic profiles between two age groups.Results: Among the common risk factors, smoking (63.3% vs 40%, p=0.011) & family history of ischeamic heart disease (21.7% vs 8.3%, p=0.040) were more common in younger group. Whereas, hypertension (41.7% vs 65.0%, p=0.010) and DM (18.3% vs 36.7%, p=0.024) were more common in older patients. Serum Homocysteine level was found significantly higher in younger patients (30.0% vs 13.3%, p=0.026). In group-I. coronary angiography revealed normal coronaries in 15 patients (25%), single vessel disease in 29 (48.3%) and multi-vessel disease in 16 patients (26.6%). Whereas, 40(66.6%) patients in group-II were found to have multi-vessel disease and 2 of them had significant left main coronary disease. However, young patients who had high serum homocysteine level showed more angiographic severity than older patients.Conclusion: There are significant differences in the clinical, biochemical and angiographic profile of young patients with ischeamic heart disease as compared to older patients. Young patients with ischeamic heart disease has got less angiographic severity, except in those with high serum homocysteine level.Cardiovasc. j. 2015; 8(1): 23-29

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“…Vários defeitos genéticos estão associados, entre eles, o acúmulo de homocisteína (Hcy) no sangue (9,14,19) . A concentração plasmática de homocisteína é influenciada tanto por fatores nutricionais, como concentração do ácido fólico e vitaminas B6 e B12, quanto por fatores hereditários, especialmente os ligados às enzimas do metabolismo da metionina e da cisteína (1) .…”

Section: Frequência Genotípica Em Amostras De Mthfr Para O Polimorfisunclassified

Frequência genotípica em amostras de MTHFR para o polimorfismo C677T em pacientes da cidade de Curitiba-PR

Herkenhoff¹,

Backes²,

Gaulke³

et al. 2012

J. Bras. Patol. Med. Lab.

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A homocisteína plasmática associada à mutação no gene da 5-metiltetra-hidrofolato (MTHFR) é considerada um fator de risco para doença coronariana. O objetivo deste trabalho foi estabelecer o número de indivíduos com essa mutação. Os exames solicitados foram enviados para o laboratório Genolab, abrangendo a cidade de Curitiba-PR. Foi utilizado o método da reação em cadeia da polimerase em tempo real (RT-PCR), tendo como base os laudos para a detecção da mutação C677T em um período dois anos. Vinte e três indivíduos possuíam o genótipo homozigoto C; nove, o homozigoto T; e 35, o heterozigoto. A detecção dessa mutação é importante para uma orientação no tratamento inicial de pacientes que possuem doenças coronarianas correlacionadas.

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Homocysteine, vitamin B12 and folate levels in premature coronary artery disease

Cited by 79 publications

References 36 publications

WITHDRAWN: Association of homocysteine-metabolizing enzyme gene polymorphisms and lipid profiles: an investigation of a geneenvironment interaction

WITHDRAWN: Association of homocysteine-metabolizing enzyme gene polymorphisms and lipid profiles: an investigation of a geneenvironment interaction

Comparison of Different Risk Factors and Coronary Angiographic Profile in Younger and Older Patients with Ischeamic Heart Disease

Frequência genotípica em amostras de MTHFR para o polimorfismo C677T em pacientes da cidade de Curitiba-PR

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