Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

Giannoni, Melania; Consales, Veronica; Campanati, Anna; Ganzetti, Giulia; Giuliodori, Katia; Postacchini, Valentina; Liberati, Giulia; Azzaretto, L.; Vichi, Silvia; Guanciarossa, F.; Offidani, Anna Maria

doi:10.1111/jdv.13023

Cited by 46 publications

(51 citation statements)

References 34 publications

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“…However, unlike these results, patients with psoriasis were found to have high blood homocysteine in other five studies again in our country and five in Italy and one each in Ireland and Norway [20][21][22][23][24][25][26][27][28][29][30][31] . In the literature, studies showing psoriasis being accompanied by high blood homocysteine seem to be predominant (Table 3).…”

contrasting

confidence: 42%

“…After the studies made in 1990s where high levels of homocysteine were found in plasma samples of subjects who had or would likely to have a history of myocardial infarction, ischemic stroke or peripheral vascular disease and the association of homocysteine with atherosclerosis and hypercoagulability had been shown [6][7][8][9][10][11][12] , along with increased attention to the comorbidities of psoriasis, as far as we know, 19 studies have been conducted to explore homocysteine levels in these patients. Homocysteine level was found to be high in 12 and normal in 7 of these studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] . Since this sulfur-containing amino acid is not taken through diet and not producing protein, homocysteine is formed via methionine catabolism 8,11,27 .…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, studies showing psoriasis being accompanied by high blood homocysteine seem to be predominant (Table 3). The reason for this coexistence is still not fully understood, but one of the propositions is that fast keratinocyte proliferation in psoriasis increases folic acid consumption or microinflammation accompanying psoriasis in colonic mucosa 43,44 reduces folic acid absorption leading to folic acid deficiency which results in elevation of homocysteine 25,26 . No folic acid deficiency was found in psoriatic patients in this study, but as in many other studies, we observed a reverse correlation between folic acid and homocysteine 11,21 .…”

mentioning

confidence: 99%

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Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

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contrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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“…However, in the study by Giannoni et al , patients with increased homocysteine levels also had decreased vitamin B 12 and folate levels. These parameters (increased homocysteine and decreased vitamin B 12 and folate) might be caused by the same determinant, which might be increased keratinocyte metabolic turnover rate in psoriasis patients [20]. On the other hand, in our study, increased homocysteine levels did not correlate with disease duration or severity, and these patients had normal vitamin B 12 and folate values.…”

Section: Discussioncontrasting

confidence: 51%

“…Thus, some reports have concluded that high homocysteine levels in patients with psoriasis are positively correlated with PASI scores, even in patients who do not have accompanying hyperhomocysteinemia risk factors. Homocysteine levels may be an independent risk factor for cardiovascular disease [19, 20]. However, in the study by Giannoni et al , patients with increased homocysteine levels also had decreased vitamin B 12 and folate levels.…”

Section: Discussionmentioning

confidence: 99%

Assessment of subclinical cardiac damage in chronic plaque psoriasis patients: a case control study

Özden¹,

Polat²,

Öztürk³

et al. 2016

Arch Med Sci Atheroscler Dis

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Introduction: Epidemiological studies have suggested that patients with psoriasis are at an increased risk of developing cardiovascular diseases. Chronic inflammation may play a role in the pathogenesis of atherosclerosis in psoriasis patients. Recent studies have evaluated the expression of plasma endocan and homocysteine levels. Endocan is a marker of vascular endothelial damage, and homocysteine plays a role in the development of atherosclerosis. Plasma endocan and homocysteine levels, as well as echocardiographic parameters, were evaluated in patients with psoriasis to assess cardiovascular disease risk. Material and methods: This was a prospective cohort analysis of 40 patients who were diagnosed with psoriasis and 40 healthy controls matched to the patient group according to demographic and biochemical parameters. Results: Serum endocan and homocysteine concentrations were significantly higher in the psoriasis group than the control group (p < 0.001). Serum endocan concentrations correlated positively with disease duration (p < 0.001; r = 0.725). The Tei index (myocardial performance) was elevated in psoriasis patients (p < 0.001). Additionally, the E/A (mitral valve early diastolic peak flow velocity/mitral valve late diastolic peak flow velocity) and E/Em (early diastolic myocardial velocity) ratios were reduced in psoriasis patients (p < 0.001). Parameters indicative of left ventricular asynchrony were elevated significantly in the psoriasis group versus the control group (p < 0.001). Conclusions: We observed a substantial increase in serum endocan and homocysteine concentrations, and significant differences in key parameters of cardiac function, in psoriasis patients relative to controls. These results are consistent with the hypothesis that subclinical cardiac damage is increased in patients with psoriasis and that psoriasis itself may be a cardiovascular risk factor.

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Research Strands in Dermatology and Gastroenterology Units of Department of Clinical and Molecular Sciences in Polytechnic Marche University

Benedetti

Campanati

Martina

et al. 2020

The First Outstanding 50 Years of “Università Politecnica Delle Marche”

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Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

Cited by 46 publications

References 34 publications

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Assessment of subclinical cardiac damage in chronic plaque psoriasis patients: a case control study

Research Strands in Dermatology and Gastroenterology Units of Department of Clinical and Molecular Sciences in Polytechnic Marche University

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