Homocysteine plasma levels in patients affected by hidradenitis suppurativa: an Italian experience

Marasca, Claudio; Donnarumma, Marianna; Annunziata, Maria Carmela; Fabbrocini, Gabriella

doi:10.1111/ced.13798

Cited by 7 publications

(2 citation statements)

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“…Innumerous factors increase the frequency of lesions as well as the severity of the disease. To complicate matters further, HS is associated with a plethora of comorbidities that include dysregulation of the 1carbon metabolism (6,20,21,(33)(34)(35). This ambiguity has led to the suggestion of many ultimate causes.…”

Section: Resultsmentioning

confidence: 99%

“…Researchers have found elevated Homocysteine (Hcy) levels in the blood plasma of HS patients (6,20). Marasca et al (21) found that not only are Hcy levels elevated in HS patients, but the Hcy levels are positively correlated with disease severity, measured by Sartorius Score. The Sartorius Score is a measure of disease severity in HS which evaluates patients based on a point system (22).…”

Section: High Fat Diet 1-carbon Metabolism and Hsmentioning

confidence: 99%

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Hidradenitis Suppurativa and 1-Carbon Metabolism: Role of Gut Microbiome, Matrix Metalloproteinases, and Hyperhomocysteinemia

et al. 2020

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Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition characterized by painful nodules which suppurate and later develop into scar tissues followed by the development of hypodermal tracts. Although the mechanisms behind HS are not fully understood, it is known that dietary factors play important roles in flare frequency and severity. We hypothesize that the high fat diet (HFD) causes dysbiosis, systemic inflammation, and hyperhomocysteinemia (HHcy) in susceptible individuals, which subsequently elevate inflammatory cytokines such as IL-1β, IL-6, IL-17, and tumor necrosis factor alpha (TNF-α). This increase in dysbiosis-led inflammation coupled with a dysregulation of the 1-carbon metabolism results in an increase in matrix metalloproteinases MMP-2, MMP-8, and MMP-9 along with tissue matrix remodeling in the development and maintenance of the lesions and tracts. This manuscript weaves together the potential roles played by the gut microbiome, HHcy, MMPs, and the 1-carbon metabolism toward HS disease causation in susceptible individuals.

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