Homocysteine Levels, Haemostatic Risk Factors and Patency Rates after Endovascular Treatment of the Above-Knee Femoro-Popliteal Artery

Abstract

Early restenosis or reocclusion after endovascular intervention of lesions in the above-knee femoro-popliteal artery was more frequent following treatment of occlusion (versus stenosis), for patients with diabetes, patients with elevated D-dimer and those without antithrombotic therapy after the procedure. Plasma homocysteine did not appear to influence the outcome of endovascular intervention.

The role of established and emerging risk factors in peripheral vascular graft occlusion

“…A study of 68 individuals subjected to vascular and endovascular surgery suggested that fibrinogen levels did not differ significantly (p = 0.510) between the stenosis (n = 23) and non-stenosis groups (n = 45) [6]. This finding was confirmed in another study in which 103 patients were treated with either subintimal angioplasty or intraluminal percutaneous transluminal angioplasty [56]. Multivariate analysis showed no significant correlation between plasma fibrinogen and patency rates [57].…”

“…In contrast, a study of 81 cases treated with percutaneous transluminal angioplasty could not reproduce this finding [73]. Another study including 103 patients treated with subintimal angioplasty or intraluminal percutaneous transluminal angioplasty showed no association between homocysteine levels and the development of reocclusion or restenosis [56]. However, patients with critical ischaemia had significantly higher values of homocysteine than patients with intermittent claudication [56].…”

“…Another study including 103 patients treated with subintimal angioplasty or intraluminal percutaneous transluminal angioplasty showed no association between homocysteine levels and the development of reocclusion or restenosis [56]. However, patients with critical ischaemia had significantly higher values of homocysteine than patients with intermittent claudication [56]. Furthermore, the patients with critical ischaemia resulting in amputation had even higher plasma homocysteine values than patients with critical ischaemia whose limbs were salvaged [56].…”

“…On the other hand, a study that investigated the influence of several plasma values, including CRP, on patency rates after endovascular treatment of the above-knee femoro-popliteal artery, suggested that there is no correlation between CRP levels and patency rates or run off [56].…”

“…On the other hand, some studies report no significant association between fibrinogen levels and risk for graft occlusion [6,56,57]. A study of 68 individuals subjected to vascular and endovascular surgery suggested that fibrinogen levels did not differ significantly (p = 0.510) between the stenosis (n = 23) and non-stenosis groups (n = 45) [6].…”