Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population

Guéant-Rodríguez, Rosa María; Spada, Rosario S.; Moreno-Garcia, Maira A.; Anello, Guido; Bosco, Paolo; Lagrost, Laurent; Romano, Antonino; Elia, Maurizio; Guéant, Jean Louis

doi:10.1016/j.atherosclerosis.2010.11.031

Cited by 29 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 125 heterozygous familial hypercholesterolemia patients, Hcy (r = −0.370, P = 0.003) and methylenetetrahydrofolate reductase (MTHFR) TT genotype were associated with low HDL values [23]. Anan et al reported similar results to those observed during the present study that Hcy is associated with TG and HDL-C, but not with TC nor LDL-C in 40 Japanese patients with diabetes [24] , Rosa et al reported that Hcy correlates negatively with ApoA-I and with HDL-C in elderly rural subjects from Sicily [25]. Focusing on Chinese subjects, in 2058 Chinese consecutive coronary artery angiographic patients, Hcy was found to be negatively correlated with HDL-C (r = −0.148, P < 0.001) [4].…”

Section: Discussionsupporting

confidence: 81%

Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population

et al. 2017

View full text Add to dashboard Cite

BackgroundPrevious studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. However, there was limited epidemic data concerning the relation between HHcy and lipid profiles, especially in community-based Chinese populations. This study aim to investigate the association of plasma homocysteine (Hcy) level with lipid profiles in a Chinese community-based population without lipid-lowering treatment.MethodA total of 4660 Chinese subjects from a cohort of the Shijingshan district in Beijing were included in the analysis. Plasma total Hcy, serum lipid files including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) as well as relevant metabolic risk factors were measured. Multivariate regression models adjusting for age, gender, smoking, drinking, physical activity, vitamin B supplement, body mass index, fasting blood glucose level, serum creatinine, systolic and diastolic blood pressure were used to evaluate associations of Hcy and lipid profiles.ResultSubjects were 56.75 ± 8.91 years old, and 38.15% were male. Median (IQR) Hcy was 11.98 (10.00–14.93) μmol/L, and 24.4% had HHcy (defined as Hcy ≥ 15 μmol/L). Mean (SD) baseline TC was 5.34 ± 0.98 mmol/L, LDL-C was 3.27 ± 0.81 mmol/L, and HDL-C was 1.43 ± 0.38 mmol/L. Median (IQR) of TG was 1.28 (0.91–1.85) mmol/L. In multivariable linear-regression analyses, lnHcy (ln transformation for Hcy) level was positively associated with lnTG (adjusted β = 0.075, SE = 0.021, P = 0.001). Using Hcy < 15 μmol/L as a reference, HHcy was independently associated with both lnTG (adjusted β = 0.056, SE = 0.020, P = 0.004) and lnHDL (adjusted β = −0.018, SE = 0.009, P = 0.038). In multivariable logistic-regression analyses, HHcy was associated with increasing risk of low HDL-C (HDL-C < 1.04 mmol/L; adjusted odds ratio [OR] =1.406, 95% confidence interval [CI]: 1.143 – 1.728, P = 0.001) and hypertriglyceridemia (TG ≥ 1.7 mmol/L; adjusted OR = 1.293, 95% CI: 1.096–1.524, P = 0.002) after adjusting the confounders. However, there were no significant associations between Hcy and TC or LDL-C.ConclusionThe present study showed that HHcy was independently associated with hypertriglyceridemia and low levels of HDL-C, which provides evidence that Hcy levels might affect HDL-C and TG metabolism.

show abstract

Section: Discussionsupporting

confidence: 81%

Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population

et al. 2017

View full text Add to dashboard Cite

show abstract

“…For example, patients with CKD exhibit significant lipoprotein derangements, including ApoA-I [29]. ApoA-I is negatively correlated with plasma Hcy, and low ApoA-I levels are a risk factor for cardiovascular disease [30]. Thus, our findings that renal ApoA-I is down-regulated by the Pon1 −/− genotype suggest that Pon1 interacts with ApoA-I and has an anti-atherogenic function in the kidney.…”

Section: Discussionmentioning

confidence: 79%

Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease

Suszyńska-Zajczyk

Sikora

Jakubowski

2014

Molecular Genetics and Metabolism

View full text Add to dashboard Cite

“…Oxidized phospholipids (OxPL) on Apo-B100-containing lipoproteins (OxPL/ApoB) and the major lipoprotein carrier of OxPL, named lipoprotein-a (Lp-a), have been reported to be positively associated with risk of PAD [73]. Additionally, apolipoprotein (Apo)-A1 and high-density lipoprotein (HDL) have previously been associated with PAD and Apo-AI and homocysteine (Hcy) were reported to be predictors of ABI [91]. It should also be noted that up to 30% of PAD patients have elevated serum levels of Hcy in comparison to 1% of the general population [17].…”

Section: Potential Biomarkers For Padmentioning

confidence: 99%

A Review of the Pathophysiology and Potential Biomarkers for Peripheral Artery Disease

Krishna

Moxon

Golledge

2015

IJMS

146

113

View full text Add to dashboard Cite

Peripheral artery disease (PAD) is due to the blockage of the arteries supplying blood to the lower limbs usually secondary to atherosclerosis. The most severe clinical manifestation of PAD is critical limb ischemia (CLI), which is associated with a risk of limb loss and mortality due to cardiovascular events. Currently CLI is mainly treated by surgical or endovascular revascularization, with few other treatments in routine clinical practice. There are a number of problems with current PAD management strategies, such as the difficulty in selecting the appropriate treatments for individual patients. Many patients undergo repeated attempts at revascularization surgery, but ultimately require an amputation. There is great interest in developing new methods to identify patients who are unlikely to benefit from revascularization and to improve management of patients unsuitable for surgery. Circulating biomarkers that predict the progression of PAD and the response to therapies could assist in the management of patients. This review provides an overview of the pathophysiology of PAD and examines the association between circulating biomarkers and PAD presence, severity and prognosis. While some currently identified circulating markers show promise, further larger studies focused on the clinical value of the biomarkers over existing risk predictors are needed.

show abstract

Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population

Cited by 29 publications

References 29 publications

Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population

Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population

Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease

A Review of the Pathophysiology and Potential Biomarkers for Peripheral Artery Disease

Contact Info

Product

Resources

About