Homocysteine in cerebral macroangiography and microangiopathy

Faβbender, Klaus; Mielke, Orell; Bertsch, Thomas; Hennerici, Michael G.

doi:10.1016/s0140-6736(99)00309-8

Cited by 169 publications

(95 citation statements)

References 3 publications

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“…This finding is concordant with previous findings from clinical studies that homocysteine levels were higher in patients with subcortical vascular encephalopathy, a type of dementia with subcortical diffuse white-matter lesions or *Adjusted for hypertension status, BMI, current alcohol intake, cigarette smoking status, serum total cholesterol levels, log-transformed triglyceride levels, quartiles of C-reactive protein, and serum glucose category as well as matching for sex, age, community, year of serum stored, and fasting status. multiple subcortical lacunae, 24 and patients with silent brain infactions 25 than in control subjects. These clinical manifestations involve the cerebral microvascular system.…”

Section: Iso Et Al Homocysteine and Risk Of Stroke In Japanese 2769mentioning

confidence: 83%

Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese

Iso¹,

Moriyama²,

Sato³

2004

ACC Current Journal Review

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Background-To date, no prospective studies have examined the association between serum homocysteine levels and the risk of stroke and stroke subtypes in Asian populations. Methods and Results-A prospective, nested, case-control study of Japanese subjects 40 to 85 years of age was conducted by using frozen serum samples from 11 846 participants in cardiovascular risk surveys collected from 1984 to 1995 for one community and 1989 to 1995 for the other two communities. By the end of 2000, we identified 150 incident strokes, the subtypes of which were confirmed by imaging studies. Three control subjects per case were selected by matching for sex, age, community, year of serum storage, and fasting status. Serum total homocysteine levels were measured by high-performance liquid chromatography. Compared with control subjects, total (nϭ150), hemorrhagic (nϭ52), and ischemic (nϭ98) strokes had higher geometric mean values of total homocysteine and higher proportions of homocysteine Ն11.0 mol/L. The multivariate odds ratios (95% CI) for highest (Ն11.0 mol/L) versus lowest quartiles (Ͻ7.0 mol/L) of homocysteine after adjustment for body mass index, smoking, alcohol intake, hypertension, serum total cholesterol, and other cardiovascular risk factors were 2.99 (1.51 to 5.93) for total stroke, 3.89 (1.60 to 9.46) for ischemic stroke, 3.36 (1.27 to 8.90) for lacunar infarction, and 1.63 (0.44 to 6.00) for hemorrhagic stroke. The respective multivariate odds ratios associated with a 5-mol/L increase in homocysteine were 1.40 (1.09 to 1.80), 1.52 (1.07 to 2.14), 1.48 (1.01 to 2.18), and 1.10 (0.76 to 1.59). The excess risk of total and ischemic strokes did not vary significantly according to sex, age, smoking status, or hypertensive status. Conclusions-High total homocysteine concentrations were associated with the increased risk of total stroke, more specifically ischemic stroke and lacunar infarction, among Japanese men and women.

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Section: Iso Et Al Homocysteine and Risk Of Stroke In Japanese 2769mentioning

confidence: 83%

Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese

Iso¹,

Moriyama²,

Sato³

2004

ACC Current Journal Review

View full text Add to dashboard Cite

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“…First, hyperhomocysteinemia has a direct prothrombotic effect on the vascular system and thus may lead to both largeand small-vessel disease. 66 Elevated homocysteine levels are also associated with the number of WMLs and progressionpossibly through direct endothelial damage or stimulation of an endothelial inflammatory response. 65,67,68 Second, hyperhomocysteinemia could impair neuronal pathways because elevated homocysteine has a direct, neurotoxic effect by activating the N-methyl-D-aspartate receptor or by conversion into homocysteic acid, leading to cell death.…”

Section: Potential Causes Of Cognitive Impairment In Patients With Ckdmentioning

confidence: 99%

Cognitive Disorders and Dementia in CKD

Bugnicourt

Godefroy

Chillon

et al. 2013

Journal of the American Society of Nephrology

478

431

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Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.

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“…Risk factors for white matter lesions, a precursor to dementia, include increased plasma homocysteine [17], decreased serum tryptophan [18], low serum antioxidant levels [19], hyperinsulinemia [20], and hyperfibrinogenemia [19]. Genetics could also be a factor, such as Cerebral Autosomal Dominant and Subcortical Ischemic Leukoencephalopathy (CADASIL), a defect on the Notch 3 gene of chromosome 19 [21], that presents young and has features of premature frontal-subcortical dysfunction.…”

Section: Risk Factorsmentioning

confidence: 99%

Vascular and Subcortical Dementia

Blose¹

2017

Vasc Med Surg

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Homocysteine in cerebral macroangiography and microangiopathy

Cited by 169 publications

References 3 publications

Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese

Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese

Cognitive Disorders and Dementia in CKD

Vascular and Subcortical Dementia

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