Homocysteine (Hcy) and cognitive performance in a population sample of elderly Brazilians

Tassino, Márcio; Campos, Tânia; Guerra, Ricardo Oliveira

doi:10.1016/j.archger.2007.12.002

Cited by 17 publications

(9 citation statements)

References 37 publications

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“…Moreover, because most previous studies examined subjects who were 65 years of age or older [10, 20–22], those studies lacked a sufficiently broad age range necessary to distinguish the effects of age from that of elevated tHcy. In addition, most research examining tHcy as a risk factor for dementia has been carried out in developed countries [10, 23–27]; few studies have addressed this issue in populations of Hispanic descent residing in the developing world, particularly in Latin America, where dietary supplementation with folate and multivitamins is uncommon [28, 29]. …”

Section: Introductionmentioning

confidence: 99%

Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population

Chacón

Molero

Pino-Ramirez

et al. 2009

International Journal of Alzheimer's Disease

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The relationship between total homocysteine (tHcy) and dementia risk remains controversial, as the association varies among populations and dementia subtypes. We studied a Venezuelan population that has high prevalence of both elevated tHcy and dementia. We tested the hypotheses that (1) elevated tHcy is associated with increased dementia risk, (2) the risk is greater for vascular dementia (VaD) than for Alzheimer's disease (AD), and (3) a history of stroke may partly explain this association. 2100 participants (≥55 years old) of the Maracaibo Aging Study underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. Elevated tHcy was significantly associated with dementia, primarily VaD. When history of stroke and other confounding factors were taken into account, elevated tHcy remained a significant risk factor in older (>66 years), but not in younger (55–66 years) subjects. Ongoing studies of this population may provide insight into the mechanism by which tHcy increases risk for dementia.

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Section: Introductionmentioning

confidence: 99%

Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population

Chacón

Molero

Pino-Ramirez

et al. 2009

International Journal of Alzheimer's Disease

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“…Although this study took into account possible confounding by niacin and vitamin E intake levels, it did rely upon participant estimations of intake via a food frequency questionnaire. Finally, a recent study by Tassino, Campos, and Guerra (2009) showed that homocysteinemia predicted a relatively low proportion (4%) of the variance in cognitive function in a group of low-income older Brazilian adults, but it is possible that the predictive power would have been larger if more sensitive outcome measures had been used.…”

Section: B Vitaminsmentioning

confidence: 99%

Supplementing Cognitive Aging: A Selective Review of the Effects of Ginkgo Biloba and a Number of Everyday Nutritional Substances

Brown

Riby

Reay

2009

Experimental Aging Research

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“…Hcy, which is secreted through the metabolism of methionine, is a sulfhydryl amino acid dependent on folic acid, pyridoxine, and vitamin B 12 ; because of this strong association, Hcy is often considered a sensitive marker of these vitamins (Tassino et al, 2009). Furthermore, serum Hcy is susceptible to a wide range of other factors such as diet, drug use, lifestyle, and certain genetic abnormalities (Jianbo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, serum Hcy is susceptible to a wide range of other factors such as diet, drug use, lifestyle, and certain genetic abnormalities (Jianbo et al, 2011). In clinical practice, Hcy has been suggested to be a predictive factor of cognitive dysfunctions, dementia, neurodegenerative pathologies, and neurovascular alterations such as in Parkinson's and Alzheimer's disease (Tassino et al, 2009). In addition, some studies have also demonstrated that the reactivity of the plasma Hcy levels may be implicated in a series of diabetic complications such as foot ulceration, cerebrovascular disease, coronary artery disease, stroke, thrombosis, and atherosclerosis (Tassino et al, 2009;Vinukonda et al, 2009;Gonzalez et al, 2010;Gazzaruso et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…In clinical practice, Hcy has been suggested to be a predictive factor of cognitive dysfunctions, dementia, neurodegenerative pathologies, and neurovascular alterations such as in Parkinson's and Alzheimer's disease (Tassino et al, 2009). In addition, some studies have also demonstrated that the reactivity of the plasma Hcy levels may be implicated in a series of diabetic complications such as foot ulceration, cerebrovascular disease, coronary artery disease, stroke, thrombosis, and atherosclerosis (Tassino et al, 2009;Vinukonda et al, 2009;Gonzalez et al, 2010;Gazzaruso et al, 2012). Moreover, recent studies have revealed that there is a significant association between plasma Hcy concentrations and the occurrence and grade of DPN (Gonzalez et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Elevated serum homocysteine level in the development of diabetic peripheral neuropathy

Zheng¹,

Zhang²,

GUAN³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, Ovid, PubMed, Web of Science, Wangfang, and China National Knowledge Infrastructure databases. All analyses were performed by using the STATA software, version 12.0 (StataCorp, College Station, TX, USA) and the Comprehensive Meta-analysis 2.0 software (Biostatic Inc., Englewood, NJ, USA). The standardized mean difference (SMD) and 95% confidence interval (95%CI) were further calculated. The electronic literature search identified six articles that included 603 patients with DPN and 687 healthy controls. The pooled SMD of those six studies revealed that increased serum levels of Hcy may be correlated with DPN (SMD = 1.23, 95%CI: 1.09-1.36, P < 0.001). Subgroup analysis 15365-15375 (2015) according to ethnicity indicated that high serum Hcy levels might be an important risk factor for DPN in both Asian and Caucasian populations (Asians: SMD = 0.62, 95%CI: 0.45-0.79, P < 0.001; Caucasians: SMD = 2.32, 95%CI: 2.10-2.55, P < 0.001; respectively). Elevated serum levels of Hcy indicate the risk of development of DPN in patients, suggesting that Hcy levels could be used as a marker for new therapeutic approaches to DPN.

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Homocysteine (Hcy) and cognitive performance in a population sample of elderly Brazilians

Cited by 17 publications

References 37 publications

Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population

Risk of Dementia Associated with Elevated Plasma Homocysteine in a Latin American Population

Supplementing Cognitive Aging: A Selective Review of the Effects of Ginkgo Biloba and a Number of Everyday Nutritional Substances

Elevated serum homocysteine level in the development of diabetic peripheral neuropathy

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