Homocysteine and Vascular Access Thrombosis in a Cohort of End‐Stage Renal Disease Patients

Bowden, Rodney G.; Wyatt, Frank; Wilson, Ronald L.; Wilborn, Collin; Gentile, Mindy

doi:10.1081/jdi-200037117

Cited by 15 publications

(16 citation statements)

References 19 publications

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“…Furthermore, no patient entered in the study had patency problems, in this way we tried to minimize the mechanical effects leading to VA thrombosis. Although thrombosis risk and plasma levels of homocysteine are greater in men than female [17][18][19], but we failed to show this association in our study.…”

Section: /4contrasting

confidence: 54%

Hyperhomocysteinemia, a Risk Factor for Arteriovenous Fistula Thrombosis in Hemodialysis Patients

Hemmati¹

2016

UNOAJ

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Purpose: Homocysteine, a putative risk factor of cardiovascular disease is considerably high in hemodialysis patients. The aim of this study was to identify the association between homocysteine level and occurrence of fistula thrombosis in newly developed hemodialytic patients with arteriovenous (AV) fistula.Method: In this prospective study 120 patients with ESRD who were candidate for AV fistula insertion, were enrolled. The association between homocysteine level, age, sex, and underlying disease leaded to ESRD and incidence of AV fistula thrombosis was analyzed by means of Logistic Regression model.

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Section: /4contrasting

confidence: 54%

Hyperhomocysteinemia, a Risk Factor for Arteriovenous Fistula Thrombosis in Hemodialysis Patients

Hemmati¹

2016

UNOAJ

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“…Paradoxically, two recent studies showed that patients with very low homocysteine plasma levels had worse outcomes including a higher incidence of hospitalization and mortality [7, 8]. This raises the question as to whether elevated homocysteine in uremic patients is consequential rather than causal in the role of cardiovascular complications [9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

5-Methyltetrahydrofolate Administration Is Associated with Prolonged Survival and Reduced Inflammation in ESRD Patients

et al. 2008

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“…Conclusions from studies examining role of this phenomenon in the context of arteriovenous fistula function are contradictory. Shemin et al (56) and Mallamaci et al (57) believe that the risk of dialysis access thrombosis is high er among patients with high serum homocysteine, while studies by Levesque et al (58) and Bowden et al (59) do not support such relationship.…”

Section: Discussionmentioning

confidence: 72%

Estimation of Predictive Factors Affecting Patency of Dialysis Arteriovenous Fistulae

Mularczyk¹,

Kostewicz²

2010

Polish Journal of Surgery

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Native arteriovenous fistula is considered the best type of access for dialysis. Its function is affected by multiple factors. the aim of the study was to identify risk factors of the loss of fistula patency. material and methods. Between 1990Between -2004 patients underwent 276 surgical procedures involving vascular access creation. In 245 (89%) of cases, a fistula was created using only patient's own blood vessels; in 31 (11%) of cases a vascular graft was implanted. 158 (64%) radio-cephalic fistulae were created, 15 (6%) radiobasilic fistulae, 33 (14%) brachiocephalic and 39 (16%) brachiobasilic fistulae. Duration of primary patency was identified for 217 native fistulae. Age, gender, diabetes mellitus, type, mode of creation and fistula location, vein translocation, type of anastomosis and time of initial cannulation were analyzed as potential factors affecting the fistula patency. Cox proportional hazards model was used in the analysis. Results. Probability of fistula patency loss in patients above 46 years of age was 2.12-fold higher than in younger patients and 1.62-fold higher for end-to-side anastomosis versus end-to-end anastomosis. Risk of loss of patency in fistulae cannulated for the first time within the first 14 days, 15-21 days and 22-35 days from their creation was 31-, 19-and 7-fold higher than when they were cannulated after the first 35 days. conclusions. Type of vascular anastomosis, age above 46 years and time of the first cannulation are independent risk factors of the loss of patency of vascular access. First cannulation should not take place earlier than 7 weeks after its creation.

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Homocysteine and Vascular Access Thrombosis in a Cohort of End‐Stage Renal Disease Patients

Cited by 15 publications

References 19 publications

Hyperhomocysteinemia, a Risk Factor for Arteriovenous Fistula Thrombosis in Hemodialysis Patients

Hyperhomocysteinemia, a Risk Factor for Arteriovenous Fistula Thrombosis in Hemodialysis Patients

5-Methyltetrahydrofolate Administration Is Associated with Prolonged Survival and Reduced Inflammation in ESRD Patients

Estimation of Predictive Factors Affecting Patency of Dialysis Arteriovenous Fistulae

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