Homocysteine and risk of open-angle glaucoma

Bleich, Stefan; Jünemann, Anselm; Ahsen, Nicolas von; Lausen, Berthold; Ritter, Katharina; Beck, Georg; Naumann, Gottfried O.H.; Kornhuber, Johannes

doi:10.1007/s007020200097

Cited by 102 publications

(86 citation statements)

References 19 publications

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“…The frequency of TT genotype in younger NTG patients in our study (38.9%) is much higher when it is compared with the results reported in different ethnic populations (2-17.9%). 10,13,14,16,[22][23][24][25][26][27][28][29] Genetic traits of a disease should be more important in younger patients than in older ones. If one has a genetic predisposition to a disease, it is likely that the disease should develop earlier.…”

Section: Discussionmentioning

confidence: 99%

“…Recent researches on the association of 677C4T MTHFR gene polymorphism and hyperhomocysteinaemia with high-tension POAG and pseudoexfoliation glaucoma revealed conflicting results and the association is not obvious. [25][26][27][28] As the barotrauma from high IOP is the primary pathogenesis of optic nerve damage in hightension POAG, there appears to be low possibility of the association between hyperhomocysteinaemia and hightension POAG.…”

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confidence: 99%

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Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma

Woo

Kim

et al. 2007

Eye

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Purpose Homozygous polymorphism of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and resultant hyperhomocysteinaemia have been established as an independent risk factor for vascular diseases. There are evidences that vascular abnormalities are involved in the pathogenesis and progression of normaltension glaucoma (NTG). In the present study, we were to find out the associations between 677C4T and 1298A4C polymorphisms of the MTHFR gene and NTG. Methods This was a retrospective, casecontrolled study enrolling 78 NTG patients and 100 controls. DNA from peripheral blood lymphocytes was extracted and the genotypes of polymorphisms (677C4T and 1298A4C) in the MTHFR gene were determined using PCR followed by restriction enzyme digestion. The frequencies of the polymorphic genotypes in the patients with NTG and controls were compared. Results The frequencies of the polymorphisms of the MTHFR gene (677C4T and 1298A4C) in the NTG patients were not significantly different from those of controls. But the younger NTG patients (age at diagnosis p45 years) showed significantly higher prevalence of 677C4T polymorphism than the older NTG patients (age at diagnosis 445 years) (TT genotype, 38.9 vs 11.9%, P ¼ 0.006, OR ¼ 4.71, 95% CI ¼ 1.49-14.9) and than the younger control subgroup (TT genotype, 38.9 vs 6.1%, P ¼ 0.001, OR ¼ 9.86, 95% CI ¼ 2.23-42.4). Conclusions The 677C4T polymorphism was significantly associated with NTG in the younger patients, while 1298A4C polymorphism was not. This suggests that 677C4T polymorphism of the MTHFR gene can be a genetic risk factor of NTG in Korean population.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma

Woo

Kim

et al. 2007

Eye

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“…In contrast, a number of studies have reported elevated plasma Hcy in patients with POAG [9,19,20]. In one [9], thermolabile methylenetetrahydrofolate reductase deficiency was thought to be causal, whereas another study [19] found no correlation.…”

Section: Pexg (N=36)mentioning

confidence: 99%

“…The association between primary open-angle glaucoma (POAG) and cardiovascular disease [7] has recently stimulated interest in the role of homocysteine (Hcy) in the pathogenesis of glaucoma [9].…”

Section: Introductionmentioning

confidence: 99%

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Levels of plasma homocysteine in pseudoexfoliation glaucoma

Tranchina

Centofanti

Oddone

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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Background To examine levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with pseudoexfoliation glaucoma (PEXG), primary open-angle glaucoma (POAG), and healthy control subjects. Methods This study included 36 patients with PEXG, 40 with POAG, and 40 age-matched healthy subjects. Fasting plasma Hcy concentrations and levels of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay; values exceeding 14 μm/l were considered elevated. Results Mean plasma Hcy was significantly higher in PEXG (16.55±7.23 μm/l) compared with POAG (13.91±3.61 μm/l) and controls (13.12±5.13 μm/l) (p=0.03 and p=0.0007 respectively).There were no statistical differences in serum vitamin B12 and folic acid levels among PEXG, POAG and control subjects (p>0.05). A moderate, although statistically significant, relationship between Hcy and folic acid levels was found in the PEXG group (R 2 =0.23, p=0.003). Hcy levels were found not to be related with folic acid or vitamin B12 in either POAG or control subjects. Conclusions In this study, plasma Hcy is significantly higher in PEXG group than the POAG and control groups. Hyper-Hcy might play a role in the pathogenesis of PEXG. Hyper-Hcy may be an independent factor stressing vasculopathy in addition to pseudoexfoliation, so might be a modifiable risk factor for PEXG.

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