Homocysteine and Internal Carotid Artery Occlusion in Ischemic Stroke

Jeong, Seul-Ki; Seo, Jin Young; Cho, Young I.

doi:10.5551/jat.4796

Cited by 14 publications

(8 citation statements)

References 39 publications

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“…Increased homocysteine levels correlate with stenosis and occlusion of intracranial vessels in patients with ischemic stroke, and it also increases stroke risk 26,27. In the current study, no differences in homocysteine concentrations were found between cancer and noncancer patients with ischemic stroke.…”

Section: Discussioncontrasting

confidence: 58%

Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

Kim

Lee

2014

J Stroke

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Background and PurposeStroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients.MethodsA retrospective review was conducted in cancer patients with ischemic stroke who were admitted to a general hospital in Busan, Korea, between January 2003 and December 2012. The risk factors and biomarkers for stroke and stroke subtypes in cancer patients were compared with age- and sex-matched noncancer patients with ischemic stroke who were admitted to the same hospital during the same period.ResultsOne hundred fifty-six cancer patients with ischemic stroke were identified. Cancer patients with ischemic stroke were found to have a significantly lower proportion of hypertension, atrial fibrillation, hyperlipidemia, and ischemic heart disease than noncancer patients with ischemic stroke. However, stroke biomarkers, such as erythrocyte sedimentation rate and high-sensitivity C-reactive protein, fibrinogen, pro-brain natriuretic peptide, and D-dimer levels, were significantly increased in cancer patients with ischemic stroke than in noncancer patients. Large-artery atherosclerosis and stroke of undetermined cause were more common in cancer patients with ischemic stroke than in noncancer patients with ischemic stroke.ConclusionsCancer patients with ischemic stroke showed different risk factors, stroke biomarkers, and stroke etiology compared with noncancer patients with ischemic stroke.

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Section: Discussioncontrasting

confidence: 58%

Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

Kim

Lee

2014

J Stroke

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“…Folate is used to reduce plasma tHcy 26) , which was independently associated with increased cerebral arterial resistance 27) and internal carotid arterial occlusion 28) , as the present authors reported previously. Folate also had modulating activity on LPL 29) , an important determinant of HDL-cholesterol 30) .…”

Section: Discussionmentioning

confidence: 51%

Serum Folate and Low-Density Lipoprotein Particle Size

Kim

Park

et al. 2010

JAT

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Aim:Nutritional parameters, such as B-vitamins, have not been studied for an association with lowdensity lipoprotein (LDL) particle size. The present study explored whether serum vitamin levels, including folate and vitamin B-12, could be associated with LDL particle size. Methods: Using a randomly selected population of 255 hospital workers, we collected detailed lipid profiles, including triglyceride (TG), high-density lipoprotein (HDL) cholesterol, and LDL particle sizes. The peak particle size of LDL was measured by density gradient ultracentrifugation and a pore gradient lipoprotein system. Serum folate and vitamin B-12 levels were measured about 1 year later and analyzed. Carotid intima-media thickness (IMT) and hepatic steatosis were diagnosed ultrasonographically, and metabolic syndrome was diagnosed using ATP criteria. Results: LDL peak particle size was significantly correlated with carotid mean IMT (r 0.16, p 0.010). Serum folate levels were significantly and positively correlated with HDL cholesterol and negatively with TG, although the latter showed borderline significance. With increasing serum folate levels, the LDL peak particle size showed a gradual independent increase, even when adjusted for age, sex, hepatic steatosis, metabolic syndrome, and the TG/HDL cholesterol ratio. Conclusion: Folate may act to enhance LDL particle size. Future clinical and research work should include a study of the safe application and manipulation of folate levels in order to control LDL particle size.

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“…It causes focal lacunar infarction and more diffuse ischaemia, referred to as leukoaraiosis [20]. Jeong and colleagues evidenced a direct influence of elevated homocysteine even on the large arteries, such as internal carotid artery [21].…”

Section: Cardiovascular Disordersmentioning

confidence: 98%

Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties

Cacciapuoti

2011

J Thromb Thrombolysis

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Increased homocysteine levels can be responsible for arterial ischemic events, such as MI, stroke or peripheral vascular disease. Homocysteine is metabolized by two pathways: re-methylation and trans-sulfuration. Both involve folic acid, and vitamins B(6-12.) Several studies assumed that the folates and vitamins B supplementation or dietary source to normalize plasma homocysteine. But, even if tends to normalize homocysteine levels, lowering homocysteine by B-group vitamins and/or folates does not reduce cardiovascular risk. In fact, recent reports confirmed that hyper-homocysteinemia is not directly responsible for cardiovascular disease, but is merely present in individuals suffering for acute and/or chronic cardiovascular events, as a collateral finding. Reduced methylation potential (MP) [due to decreased S-adenosyl-methionine (AdoMet)/S-adenosyl-homocysteine (AdoHcy) ratio] induced by the elevated plasma homocysteine levels seems to be the true responsible for cardiovascular diseases (CVD). The pathogenic mechanisms responsible for CVD appear to be dependent of DNA hypomethylation inducing an inhibition of cyclin A transcription and a reduction of endothelial cells growth. But, other human studies performed in a wide range are requested.

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Homocysteine and Internal Carotid Artery Occlusion in Ischemic Stroke

Cited by 14 publications

References 39 publications

Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

Serum Folate and Low-Density Lipoprotein Particle Size

Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties

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