Homocitrulline: a new marker for differentiating acute from chronic renal failure

Desmons, Aurore; Jaisson, Stéphane; Piètrement, Christine; Rieu, Philippe; Wynckel, Alain; Gillery, Philippe

doi:10.1515/cclm-2015-0398

Cited by 25 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these have been in discussed in the original publications that we cited above. It should be noted here that other modifications have been recently reported by Glomb, Gillery and their respective colleagues, some of which are present or expected to be found in human collagen, such as homocitrulline[34,35]. …”

Section: Similarities and Discrepancies With Other Studies Of Type 1 mentioning

confidence: 76%

The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes

2016

View full text Add to dashboard Cite

To date more than 20 glycation products were identified, of which ~15 in the insoluble human skin collagen fraction. The goal of this review is to streamline 30 yrs of research and ask a set of important questions: in Type 1 diabetes which glycation products correlate best with 1) past mean glycemia 2) reversibility with improved glycemic control , 2) cross-sectional severity of retinopathy, nephropathy and neuropathy and 3) the future long-term risk of progression of micro- and subclinical macrovascular disease. The trio of glycemia related glycation markers furosine (FUR)/fructose-lysine (FL), glucosepane and methylglyoxal hydroimidazolone (MG-H1) emerges as extraordinarily strong predictors of existing and future microvascular disease progression risk despite adjustment for both past and prospective A1c levels. X2 values are up to 25.1, p values generally less than 0.0001, and significance remains after adjustment for various factors such as A1c, former treatment group, log albumin excretion rate, abnormal autonomic nerve function and LDL levels at baseline. In contrast, subclinical cardiovascular progression is more weakly correlated with AGEs/glycemia with X2 values < 5.0 and p values generally < 0.05 after all adjustments. Except for future carotid intima-media thickness, which correlates with total AGE burden (MG-H1, pentosidine, fluorophore LW-1 and decreased collagen solubility), adjusted FUR and Collagen Fluorescence (CLF) are the strongest markers for future coronary artery calcium deposition, while cardiac hypertrophy is associated with LW-1 and CLF adjusted for A1c. We conclude that a robust clinical skin biopsy AGE risk panel for microvascular disease should include at least FUR/FL, glucosepane and MG-H1, while a macrovascular disease risk panel should include at least FL/FUR, MG-H1, LW-1 and CLF.

show abstract

Section: Similarities and Discrepancies With Other Studies Of Type 1 mentioning

confidence: 76%

The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes

2016

View full text Add to dashboard Cite

show abstract

“…Because uraemia is the main cause of increased carbamylation ( 12 ), and consequently of cHb formation, samples from 7 patients with increased blood urea (> 7.15 mmol/L) were assayed by both methods. Negative absolute and relative biases were evidenced in all samples with increased blood urea.…”

Section: Resultsmentioning

confidence: 99%

Labile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA1c measurement

et al. 2017

Self Cite

View full text Add to dashboard Cite

IntroductionHaemoglobin A1c (HbA1c) is a key analyte for the monitoring of glycemic balance in diabetic patients and is used for diabetes diagnosis in many countries. The potential interference of carbamylated haemoglobin (cHb) and labile glycated haemoglobin (LA1c) on HbA1c assays must remain a matter of vigilance. Such a situation has occurred in our laboratory with a kit replacement on the Bio-Rad Variant™ II testing system, a cation-exchange high performance liquid chromatography (HPLC) system. With this method, LA1c and cHb coeluted in a same peak which may have different consequences on HbA1c values.Materials and methodsThe influence of increasing LA1c and cHb values on HbA1c results was studied with in vitro glycation and carbamylation of samples. Samples from patients with high and normal blood urea concentrations were assayed by HPLC and immunological assay.ResultsWe observed that the degree of interference greatly varied depending on the nature of the interfering Hb fractions found under the so-called “LA1c peak”. Thus, we have decided to apply a decision tree using “LA1c” thresholds depending on: (i) the retention time, (ii) the shape of the peak, (iii) other analytes, like urea. If the peak recognized as “LA1c” is mainly formed by LA1c, we consider that there is no interference until 4%. If the peak is mainly formed by cHb, we consider an interference threshold equal to 2%.ConclusionsThis situation reminds that cHb and LA1c remain critical issues in chromatography-based HbA1c assays and that adapted criteria must be set up for result interpretation.

show abstract

“…Thus, HCit may be considered a useful clinical marker in non-HD as well as in HD patients. In non-HD patients, HCit could be used for differentiating acute from chronic renal failure [12], and we could imagine that a cutoff HCit value may help clinicians to decide the most appropriate time for initiating HD therapy. However, this hypothesis has to be evaluated after additional clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…Quantification of serum HCit was performed by LC-MS/MS as previously described [12]. HCit concentrations were expressed as μmol HCit per mol, which has also been quantified by LC-MS/MS [17].…”

Section: Quantification Of Carbamylation-derived Productsmentioning

confidence: 99%

“…For instance, the increase of serum protein-bound HCit concentrations is a risk factor for mortality in CKD patients [11]. Another example is the determination of cut-off values of HCit concentrations for differentiating acute from chronic renal failure [12]. Moreover, HCit has also been described as a valuable biomarker of morbidity and mortality in non-uremic contexts such as chronic systolic heart failure [13] or coronary artery disease [3,14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Homocitrulline as marker of protein carbamylation in hemodialyzed patients

Jaisson

Kazes

Desmons

et al. 2016

Clinica Chimica Acta

Self Cite

View full text Add to dashboard Cite

Homocitrulline: a new marker for differentiating acute from chronic renal failure

Abstract: Our results demonstrate that HCit is a promising biomarker for distinguishing between ARF and CRF patients.

Cited by 25 publications

References 24 publications

The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes

The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes

Labile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA1c measurement

Homocitrulline as marker of protein carbamylation in hemodialyzed patients

Contact Info

Product

Resources

About