Homocisteína y progresión de la aterosclerosis de la arteria carótida en pacientes con enfermedad coronaria

Fernández‐Miranda, Consuelo; Paz, Manuel; Aranda, José Luis; Núñez, Víctor; Gómez, Pilar; Díaz-Rubio, Pilar; Martínez, Joaquín; Cámara, Agustı́n Gómez de la

doi:10.1016/s0025-7753(03)74017-2

Cited by 7 publications

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“…The moderate elevation of homocysteine serum concentrations represents a risk factor for atherothrombosis (8,9). Hyperhomocysteinemia has been described in patients with IBD over the last few years, and it has been associated with the higher risk of thromboembolism in these patients (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C→T and 1298A→C mutations in patients with inflammatory bowel disease

Fernández‐Miranda

Prieto

Herce

et al. 2005

Rev. esp. enferm. dig.

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Background: hyperhomocysteinemia has been recently described in patients with inflammatory bowel disease (IBD), that could be related to the increased risk for thrombosis that exists in this disease. The aim of this study was the assessment of hyperhomocysteinemia in patients with IBD and its relation among vitamin B 12 and folate levels, and methylenetetrahydrofolate reductase (MTHFR) 677C→ T and 1298A→C mutations.Patients and methods: fifty two consecutive patients with IBD were studied (29 women and 23 men); age: mean (standard deviation 41.7 [11.9] years) and 186 controls with no difference in age and gender. Hyperhomocysteinemia was considered as homocysteine levels higher than mean plus two standard deviations of the control group (≥ 13 µmol/l).Results: patients had an elevated prevalence of hyperhomocysteinemia (17.3 vs. 3.7%; p = 0.002) and lower folate (7.6 [4.1] vs. 8.9 [3.7] ng/ml; p = 0.01) and B 12 vitamin levels (499 [287] vs. 603 [231] pg/ml; p = 0.003). Homocysteinemia was higher (14.3 [5.8] vs. 9.1 [3.9] µmol/l; p = 0.006) in 6 patients (11.5%) that had suffered thromboembolism. Frequency of MTH-FR 677C→T (13.5 vs. 11.3%; p = 0.66) and 1298A→C (7.8 vs. 7.0%; p = 0.76) mutations was not increased in patients. Odds ratio (OR) for IBD in hyperhomocysteinemic patient was 5.51, 95% confidence interval (CI), 1.81-16.76; p = 0.002). Hyperhomocysteinemia was negatively associated with feminine gender (OR 0.08, 95% CI 0.01-0.49; p = 0.006) and folate levels (OR 0.04, 95%CI: 0.007-0.20; p < 0.001).Conclusions: hyperhomocysteinemia is associated with IBD and low folate levels, and could be involved in development of thromboembolism. MTHFR 677C→T and 1298A→C mutations are not related with the disease.

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