Homochiral Metal–Organic Frameworks with Enantiopure Proline Units for the Catalytic Synthesis of β-Lactams

Abstract

Two enantiopure organic ligands integrating flexible proline units and rigid isophthalate units have been rationally designed and employed for the construction of four homochiral porous metal-organic frameworks (MOFs), respectively. One pair of these MOFs is used as heterogeneous catalysts to construct β-lactam derivatives by oxidative coupling reactions.

Tetrazine‐Based Metal‐Organic Frameworks as Scaffolds for Post‐Synthetic Modification by the Click Reaction

“…Because of the high variability of porosity, surface area, topology, and tunable chemical nature, this class of materials is a rapidly growing area of research . As a result, MOFs are investigated for a variety of potential applications including, gas storage and separations, heterogeneous catalysis, sensing, and drug delivery . It has been shown, that for certain catalyzed reactions the catalytic centers need to be isolated in order to achieve high catalytic activity , .…”

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“…2). 71 Constructing size-matching MOFs for chiral recognition is particularly attractive yet challenging. 72,73 The reaction of L2 and Cd(II) resulted in one pair enantiomeric MOFs with four kinds of helical chains existing in the structure, and the absolute helicity of these chains is attributed to the chirality of the ligand.…”

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“…Perspective which continue to be in great demand as antibiotics. An elegant example of such work is described by Xu et al 103 These workers selected an enantiopure ligand (composed of proline units) to impart homochirality on the well-known HKUST MOF (shown in Fig. 19).…”