Homicidal ideation with intent during a manic episode triggered by antidepressant medication in a man with brain injury

Dealberto, Marie-José; Marino, Josie; Bourgon, Luc

doi:10.1111/j.1399-5618.2008.00523.x

Cited by 8 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, unopposed selective serotonin reuptake inhibitors are prescribed routinely and appropriately for the treatment of posttraumatic disturbances of affect and behavioral dyscontrol syndromes, a practice that is generally inadvisable among persons with secondary mania or mixed states. 79 …”

Section: Manic Hypomanic and Mixed Disordersmentioning

confidence: 99%

Mood Disorders After TBI

Jorge

Arciniegas

2014

Psychiatric Clinics of North America

109

View full text Add to dashboard Cite

Synopsis In this article, we will examine the epidemiology and risk factors for the development of the most common mood disorders observed in the aftermath of TBI: depressive disorders and bipolar spectrum disorders. We will describe the classification approach and diagnostic criteria proposed in the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-V). We will also examine the differential diagnosis of post-TBI mood disorders and describe the mainstay of the evaluation process. Finally, we will place a special emphasis on the analysis of the different therapeutic options and provide guidelines for the appropriate management of these conditions.

show abstract

Section: Manic Hypomanic and Mixed Disordersmentioning

confidence: 99%

Mood Disorders After TBI

Jorge

Arciniegas

2014

Psychiatric Clinics of North America

109

View full text Add to dashboard Cite

show abstract

“…As it raises, the possibility of the sensitizing role of brain injury for anti-depressant-induced mania. [ 10 ] Further research on long-term follow-up of patients with the organic bipolar disorder may lead to better understanding of clinical features, prognosis, and treatment.…”

Section: Discussionmentioning

confidence: 99%

Organic Bipolar Disorder: An Unusual Neuropsychiatric Sequelae following Right Frontotemporal Injury

Ummar¹,

Kumar²,

Ramanathan³

2016

Indian Journal of Psychological Medicine

View full text Add to dashboard Cite

Psychiatric disorders are common consequences of traumatic brain injury (TBI). But organic bipolar disorder is a rare entity when compared with other disorders. Here, we report this 49 year old patient with bipolar affective disorder following traumatic brain injury, its presentation and management. Though the pathophysiology of this disorder involves the interaction of factors that precede trauma (eg, genetic vulnerability and previous psychiatric history), factors that pertain to the traumatic injury itself (eg, type, extent, and location of brain damage), in our patient it showed an atypical presentation.

show abstract

“…Nevertheless, for many of the medications discussed in this paper, it is mechanistically conceivable, due to the known adverse effect profiles, that sufficient agitation and irritability could cause HI in certain individuals. Indeed, the antidepressants [7,11] and numerous other drugs report aggression and hostility in association with their use [9]. Further, when considering motive during the sentencing of criminals, it can be instructive to access the potential role of medication use at the time of homicide.…”

Section: Discussionmentioning

confidence: 99%

Homicidal ideation causally related to therapeutic medications

Marks

Breggin²,

Braslow³

2008

International Journal of Risk and Safety in Medicine

View full text Add to dashboard Cite

Five patients with hepatitis C (HCV), three of whom were treated with interferon alpha 2 (IFN) and two who were not treated with IFN, developed homicidal ideation (HI) during a four-year period. Following accepted rules for determining causation, there appeared to be a causal relatedness between IFN use and the development of homicidal ideation for those patients taking IFN. None of these patients attempted a homicidal act while on treatment with IFN, nor in the follow up period after treatment. The incidence of HI while treated with IFN in our patient population is estimated to be <1%. The ability of prescription medication to cause homicidal ideation is reviewed, and legal implications are discussed.

show abstract

Homicidal ideation with intent during a manic episode triggered by antidepressant medication in a man with brain injury

Abstract: Further studies are needed to assess the role of brain injury as a risk factor for antidepressant-induced mania. Physicians should be cautious when prescribing antidepressants to patients with prior brain injury and inform them and their relatives of the possibility of a switch into mania.

Cited by 8 publications

References 17 publications

Mood Disorders After TBI

Mood Disorders After TBI

Organic Bipolar Disorder: An Unusual Neuropsychiatric Sequelae following Right Frontotemporal Injury

Homicidal ideation causally related to therapeutic medications

Contact Info

Product

Resources

About