“…Ca 2+ signaling is a fundamental mechanism involved in a multitude of cellular processes, including proliferation, differentiation, apoptosis, gene transcription and specialized cell functions such as neuronal activity, secretion, contraction [62] and taste perception [63]. Homer proteins are known to play key roles in various types of Ca 2+ signaling by directly or indirectly modulating the activities of Ca 2+ -handling proteins in a wide variety of cell types, including neurons [7,8,13,14,37,38,64], acinar cells of the pancreas [32] and parotid glands [33], platelets [39], striated [34,58] and smooth [40] muscle, T cells [65], osteoblasts [66] and osteoclasts [67].…”