“…Thus haemorrhage, surgery, diuretics, bacterial toxins, nervous stimulation, and occlusion of the renal artery can increase the concentration or activity of renin in blood (Vander, 1965;Brown et al, 1966aBrown et al, , 1966bMcKenzie et al, 1967;Vaughn et al, 1967;Hosie et al, 1970). Also, when sufficiently intense, each of these stimuli is capable of producing acute renal failure or acute tubular necrosis (Scarff and Keele, 1943;Phillips et al, 1946;Trueta et al, 1947;Clute and Fitzgerald, 1948;Schroeder, 1949;Daniel et al, 1952;Bull et al, 1955;Merrill, 1960;Shear et al, 1965).…”