Homeostatic non-shivering thermogenesis in humans facts and hypotheses

Сонькин, В. Д.; Kirdin, A. A.; Андреев, Р. С.; Акимов, Е. Б.

doi:10.1134/s0362119710050129

Cited by 10 publications

(9 citation statements)

References 118 publications

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“…Our data presented in this paper show that the functional response of nonshivering thermogenesis to the standard cold test after a 6 week treadmill training cycle hardly changed. This fact does not confirm our hypothesis [3] on the function of BAT as a universal homeostatic instrument in the body.…”

Section: Discussioncontrasting

confidence: 98%

“…It was also demonstrated that BAT cells contain a specific carrier (membrane transporter) that ensures a rapid penetration of lactic acid molecules into the cell and that its activity drastically increases as a result of physical training [7,8]. The authors of [8] made a conclusion that almost repeated our hypothesis about the role of BAT in the metabolism of lactic acid during exercise [3]. On the other hand, a number of papers were published in which infrared thermography is regarded as a sufficiently adequate method to study the thermogenic activity of BAT during dynamic observa tions on healthy subjects, including children [9][10][11].…”

mentioning

confidence: 89%

“…We assumed that this correlation is due to the activity of brown adipose tissue (BAT), which plays a homeo static role during physical load. It was shown first experimentally [2] and then theoretically (on the basis of published data [3]) that BAT, which is known to be involved in maintaining temperature and carbohy drate homeostasis, is likely to maintain the acid-base equilibrium during muscular work due to its ability to utilize lactic acid.…”

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confidence: 99%

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Effect of training on treadmill performance, aerobic capacity, and body responses to acute cold exposure

et al. 2014

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An attempt was made to test the hypothesis that regular physical activity at the anaerobic thresh old can stimulate an increase in the amount of brown or beige body fat, which can manifest itself in increased lactate utilization during exercise and increased reactivity in response to acute regional cooling. The methods used in the study included the ramp test; regional acute cold exposure; measurement of gas exchange; lactate and glucose in the blood; heart rate; heart rate, blood pressure, and respiration variability at rest and during standard functional tests; infrared thermal imaging; and statistical methods of analysis of results. Training of ten physically active volunteers (7 males and 3 females) on a treadmill at a speed corresponding to 75-80% of personal maximum oxygen consumption ( ) for 30 min 3 times per week at a fixed ambient temper ature of 21-22°C for 6 weeks resulted in a significant (from 19 to 39%) increase in exercise duration in the ramp test, whereas changed, on average, only slightly. The increase in the anaerobic threshold power was associated with a sharp slowdown in the accumulation of lactate during the ramp test. The lactate utili zation rate during the recovery period, on the contrary, increased. In general, work efficiency during test load significantly increased. Noticeable changes in the condition and responses to the standard functional tests of the autonomic system were not found, as judged by the heart rate variability, blood pressure, and respiration variability at rest and during orthostatic tests and imposed breathing rhythm. The functional response of the body to acute cold exposure (1 min cooling of the feet in ice water) did not change after a cycle of training, both in terms of metabolism (oxygen consumption, etc.) and the skin temperature dynamics in the areas of most probable location of brown adipose tissue (BAT). These data do not confirm our previous hypothesis (2010) about the function of BAT as a universal homeostatic instrument in the body. Probably, if the forma tion of the beige adipose tissue is stimulated by physical activity and hormone irisin, produced by muscles, this tissue is involved in lactate utilization but is not involved in the thermoregulatory responses.

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Section: Discussioncontrasting

confidence: 98%

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confidence: 89%

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confidence: 99%

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Effect of training on treadmill performance, aerobic capacity, and body responses to acute cold exposure

et al. 2014

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“…For a child they are mainly, "nonshivering thermogenesis", localized in metabolically active tissues -liver and brown adipose tissue (Brück, 1970;Kornienko, 1979). Researches of the latest years have revealed that an acute short-term cooling of adults also results in activation of nonshivering thermogenesis in brown adipose tissue (Nedergaard et al, 2007;Son'kin et al, 2010), which is proved to be preserved for most adults residing in a moderate climatic zone (Nedergaard & Cannon, 2010). Another mechanism of thermogenesis is a cold-induced muscle tremor which is usually observed in adults when the cooling effect is strengthened or prolonged.…”

Section: Thermoregulation Development In Ontogenesismentioning

confidence: 99%

“…But even in this case it is unclear which particular tissue accounts for extra heat production. Recently brown adipose tissue has been considered as the reason (Himms-Hagen, 1989;Nedergaard & Cannon, 2010), which, according to recent data, is preserved in adults (Nedergaard et al, 2007) and maintains substrate homeostasis (Son'kin et al, 2010). A unique systematic research of age changes in the thermogenic effect of food substance (glucose) in school children was made in the laboratory of I.A.Kornienko (Kornienko et al, 1984).…”

Section: Specific -Dynamic (Thermogenic) Effect Of Foodmentioning

confidence: 99%