Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome: Consequences of obesity in children and adolescents

Barseem, Naglaa Fathy; Helwa, Mohamed A

doi:10.1016/j.epag.2014.12.001

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…Therefore, IR often occurs in obese people. Our results confirmed that HOMA-IR was positively correlated with BMI, which was consistent with a previous report by Barseem and Helwa (2015). Furthermore, our results demonstrated that obese children were prone to blood lipid disorders, as they showed significantly higher serum TC, TG, and LDL-C levels as compared with controls.…”

Section: Discussionsupporting

confidence: 93%

Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity

Zhang¹,

Li²,

Wang

2017

Genet. Mol. Res.

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Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate the role of obestatin in insulin resistance. A total of 54 children with simple obesity and 57 healthy controls were recruited. Levels of serum insulin, fasting blood glucose, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein were measured. Serum obestatin level was determined using an enzyme-linked immunosorbent assay. We found that body mass index and waist-hip ratio of obese children were significantly higher, while obestatin level in the obese group was significantly lower (P < 0.001), as compared to those of controls. In addition, obese children exhibited higher levels of insulin, total cholesterol, triglyceride, and low-density lipoprotein (P < 0.05) as compared to the controls. Fasting blood glucose and high-density lipoprotein levels were similar between the two groups (P > 0.05). Leptin level in the obese group was also higher (P < 0.05) as compared to that of control group. Results showed that insulin resistance index was positively correlated with body mass index, waist-hip ratio (r = 0.41, P < 0.001; r = 0.245, P < 0.001), and triglyceride level (r = 0.25, P = 0.04). Our study demonstrated that obestatin is negatively correlated with fasting insulin and leptin levels, and positively correlated with insulin resistance in obese children.

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Section: Discussionsupporting

confidence: 93%

Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity

Zhang¹,

Li²,

Wang

2017

Genet. Mol. Res.

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“…These findings that raised BMI decreases serum insulin because of decreased vitamin d receptors due to obesity is in accordance with several studies carried out previously. 19 Increased free fatty acid levels (FFA) in obesity result in insulin resistance by inhibiting the transport of glucose into the cell, its phosphorylation and oxidation. 20 Insulin produced under a condition of insulin resistance does not act as efficiently as in the normal insulin-sensitive state, leading to an ineffective cellular utilization of glucose which may lead to immunity backfire.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum vitamin D and insulin resistance in normal weight and overweight or obese men.

Iqbal¹,

Shah²,

Sikandar³

2019

TPMJ

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Obesity is a common clinical disorder featuring excessive buildup of body fat. The bioavailability of vitamin D in obese subjects is lowered because of its sequestration in the superfluous fat tissue. Hypovitaminosis D itself is associated with glucose intolerance, insulin resistance, dyslipidemia and hypertension, which are also linked to obesity. Objectives: To compare and correlate serum vitamin D and insulin resistance in controls and overweight / obese males. Study Design: Cross Sectional, Comparative Study. Setting: The study was conducted in the Department of Physiology, Post – Graduate Medical Institute (PGMI) in collaboration with Lahore General Hospital and Central Park Medical College. Period: From 7th June 2018 to 10th Oct 2018. Material and Methods: Eighty male subjects (age range 35-50 years) included in this cross-sectional comparative study were divided into two groups on the basis of BMI; Group I: non-obese (control) BMI < 25 Kg/m2 (n=40) and Group II: overweight / obese males with BMI ˃25 Kg/m2 (n=40). Fasting serum vitamin D (25 hydroxy cholecalciferol; 25-OH D, serum insulin and blood glucose levels were measured. Insulin resistance (IR) was estimated from fasting serum glucose levels taken in mmol/l and the fasting serum insulin taken in µIU/ml by using Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR index). Results: Group II had lower serum 25-OH vitamin D levels and higher HOMA-IR index than control group. Significant negative correlation was present between serum vitamin D and HOMA-IR. Conclusion: Vitamin D deficiency may promote insulin resistance in overweight or obese individuals.

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“…Nonetheless, the HOMA-IR is well accepted by researchers and used in epidemiological studies to determine insulin resistance in adults, children and adolescents as a simplified option to the more expensive and sophisticated IR assessment methodologies. 6 , 12 , 30 - 34 Several authors have proposed cutoff points to identify IR in adolescents based on the HOMA-IR index 9 - 12 and the Receiver Operating Characteristics Curve is one of the statistical methods most commonly used for this purpose. This tool is often used in clinical and epidemiological studies that aim to determine cutoffs for diagnostic methods.…”

Section: Discussionmentioning

confidence: 99%

“… 3 - 5 The most commonly used methods for determining IR in epidemiological studies are obtained from practical formulas that use fasting glucose and insulin levels, as the Fasting Glucose/Insulin Ratio (FGIR), the Quantitative insulin sensitivity check index (QUICKI) and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), which has been frequently validated in children and adolescents and is recommended as the most sensitive and specific method for assessing insulin sensitivity in this population. 6 - 8 It is noteworthy that one of the important aspects to be observed in the successful application of HOMA-IR index in a given population is the use of specific cutoffs for gender, ethnicity, age and/or sexual maturation level (if used in adolescents). For this reason, several cutoff points have been recommended for the diagnosis of IR based on the index.…”

Section: Introductionmentioning

confidence: 99%

Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review

Andrade

Oliveira

Leal

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective:To identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents.Data source:A systematic review was performed in the PubMed, Lilacs and SciELO databases, using the following descriptors: "adolescents", "insulin resistance" and "Receiver Operating Characteristics Curve". Original articles carried out with adolescents published between 2005 and 2015 in Portuguese, English or Spanish languages, which included the statistical analysis using Receiver Operating Characteristics Curve to determine the index cutoff (HOMA-IR) were included.Data synthesis:A total of 184 articles were identified and after the study phases were applied, seven articles were selected for the review. All selected studies established their cutoffs using a Receiver Operating Characteristics Curve, with the lowest observed cutoff of 1.65 for girls and 1.95 for boys and the highest of 3.82 for girls and 5.22 for boys. Of the studies analyzed, one proposed external validity, recommending the use of the HOMA-IR cutoff>2.5 for both genders.Conclusions:The HOMA-IR index constitutes a reliable method for the detection of insulin resistance in adolescents, as long as it uses cutoffs that are more adequate for the reality of the study population, allowing early diagnosis of insulin resistance and enabling multidisciplinary interventions aiming at health promotion of this population.

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Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome: Consequences of obesity in children and adolescents

Cited by 18 publications

References 33 publications

Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity

Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity

Relationship between serum vitamin D and insulin resistance in normal weight and overweight or obese men.

Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review

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