Homeostatic control of deep sleep and molecular correlates of sleep pressure in Drosophila
Budhaditya Chowdhury,
Lakshman Abhilash,
Antonio Ortega
et al.
Abstract:Homeostatic control of sleep is typically addressed through mechanical stimulation-induced forced wakefulness and the measurement of subsequent increases in sleep. A major confound attends this approach: biological responses to deprivation may reflect a direct response to the mechanical insult rather than to the loss of sleep. Similar confounds accompany all forms of sleep deprivation and represent a major challenge to the field. Here, we describe a new paradigm for sleep deprivation in Drosophila that fully a… Show more
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