“…Similar to reactive oxygen species (ROS), reactive nitrogen species (RNS) are considered to be another physiological regulatory species for inducing damage to biomacromolecules (i.e., lipids, proteins, and DNA) through enhanced nitrosative stress. − Nitrosative stress is a biological process derived from the biochemical interaction of nitric oxide (NO) or NO-derived RNS with ROS, which plays a key role in the pathophysiology of various diseases, such as myocardial ischemic reperfusion injury, atherosclerosis, heart failure, hypertension, etc. − Intracellular nitrosative stress is mainly the result of the rate of RNS production exceeding the neutralization capacity of cells, which induces intracellular protein tyrosine nitration through the peroxynitrite (ONOO – ), nitrite, hydrogen peroxide, or peroxidase pathways, resulting in a series of cellular damage. − Recently, Bu et al reported an electrophilic zeolitic imidazole framework electrophilic (ZIF-82-PVP) for releasing nitrite to suppress autophagy and enhance nitrosative stress-mediated hypoxic prostate cancer therapy . Among reported radical species, ONOO – , derived from the diffusion-limited reaction of superoxide (O 2 •– ) with NO, is the most potential oxidizing and nitrating inducer of cell apoptosis. − The resulting ONOO – appears to be much more toxic than ROS, including hydroxyl radicals .…”