Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials

Jacobs, Jennifer; Jonas, Wayne B.; Jiménez‐Pérez, Margarita; Crothers, Dean

doi:10.1097/01.inf.0000055096.25724.48

Cited by 98 publications

(52 citation statements)

References 21 publications

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“…This represents a nonindividualized prescription in an acute clinical condition. Jacobs et al (2003) have run a series of successful trials of individualized prescriptions in the acute setting of childhood diarrhea. Understanding the therapeutic strategy we use along with the choice of condition, whether acute or chronic is essential in trial design.…”

Section: Homeopathy For Estrogenmentioning

confidence: 99%

A Pilot, Randomized, Double-Blinded, Placebo-Controlled Trial of Individualized Homeopathy for Symptoms of Estrogen Withdrawal in Breast-Cancer Survivors

Thompson

Montgomery

Douglas

et al. 2005

The Journal of Alternative and Complementary Medicine

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Improvements were seen for symptom scores over the study period. However, presuming these improvements were caused by the individualized homeopathic approach, the study failed to show clearly that the specific effect of the remedy added further to the nonspecific effects of the consultation. Future trial design must ensure adequate power to account for the nonspecific impact of such complex individualized interventions while pragmatic designs may more readily answer questions of clinical and cost effectiveness.

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Section: Homeopathy For Estrogenmentioning

confidence: 99%

A Pilot, Randomized, Double-Blinded, Placebo-Controlled Trial of Individualized Homeopathy for Symptoms of Estrogen Withdrawal in Breast-Cancer Survivors

Thompson

Montgomery

Douglas

et al. 2005

The Journal of Alternative and Complementary Medicine

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“…The principle of "potencies" states that remedies retain biological activity if they are diluted and agitated or shaken between serial dilutions, even when diluted beyond Avogadro's number, at which no original molecules remain. Even though homoeopathy is one of the most controversial types of alternative medicines, several studies have been conducted to assess the efficacy of homoeopathy in different clinical conditions, reporting positive results as well as the same placebo effect [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Homotoxicological remedies versus desmopressin versus placebo in the treatment of enuresis: a randomised, double-blind, controlled trial

et al. 2007

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The aim of this trial was to compare the safety and efficacy of homotoxicological remedies versus placebo and versus desmopressin (dDAVP) in the treatment of monosymptomatic nocturnal enuresis (MNE). We conducted a randomised, double-blind, double-dummy, controlled trial in which 151 children with MNE were randomly assigned to receive oral homotoxicological remedies (n = 50), dDAVP (n = 50) or placebo (n = 51). The primary outcomes were: the reduction of wet nights per week after 3 months of therapy; the evaluation of the numbers and percentages of non-responders and responders; the number of children relapsing after initial response and the number of children attaining 14 consecutive dry nights during the treatment. The secondary outcome was the detection of adverse effects. Baseline clinical characteristics were similar in the three groups of patients. After the 3 months of therapy there was a significant difference between the three groups (P< 0.001) in the mean number of wet nights per week. The daily dose of dDAVP produced a statistically significant decrease (62.9%) in wet nights compared to placebo (2.4%) (P < 0.001) and compared to homotoxicological remedies (30.0%) (P < 0.001). There was a significant decrease in wet nights among the group treated with homotoxicological medications if compared with placebo (P < 0.001). The full response achieved with homotoxicological remedies (20%) was superior if compared with placebo (0%) (P < 0.001). Homotoxicology was superior to placebo (P < 0.001) with regard to the number of children attaining 14 consecutive dry nights during treatment. Our study demonstrates that homotoxicology is safe and effective when compared with placebo, even if it is significantly less effective than dDAVP in this clinical condition.

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“…ʈ, 90 In addition, meta-analyses and reviews of several specific diagnoses have been carried out. 86,[91][92][93][94][95][96][97][98] Most of these reviews and meta-analyses, with some exceptions, [99][100][101] reached the conclusion that the effects observed in all trials are not compatible with the hypothesis that homeopathy is identical with placebo but that too few trials exist in any single clinical areas to recommend homeopathy clinically. Whether homeopathy is a placebo or not is also dependent on the inclusion and analysis criteria used by a meta-analysis or a review.…”

Section: Therapeutic Trialsmentioning

confidence: 99%

Research on Homeopathy: State of the Art

Walach

Jonas²,

Ives³

et al. 2005

The Journal of Alternative and Complementary Medicine

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In this paper, we review research on homeopathy from four perspectives, focusing on reviews and some landmark studies. These perspectives are laboratory studies, clinical trials, observational studies, and theoretical work. In laboratory models, numerous effects and anomalies have been reported. However, no single model has been sufficiently widely replicated. Instead, researchers have focused on ever-new models and experiments, leaving the picture of scattered anomalies without coherence. Basic research, trying to elucidate a purported difference between homeopathic remedies and control solutions has also produced some encouraging results, but again, series of independent replications are missing. While there are nearly 200 reports on clinical trials, few series have been conducted for single conditions. Some of these series document clinically useful effects and differences against placebo and some series do not. Observational research into uncontrolled homeopathic practice documents consistently strong therapeutic effects and sustained satisfaction in patients. We suggest that this scattered picture has to do with the fourth line of research: lack of a good theory. Some of the extant theoretical models are reviewed, including placebo, water structure, silica contamination, energy models, and entanglement models. It emerges that local models, suggesting some change in structure in the solvent, are far from convincing. The nonlocal models proposed would predict that it is impossible to nail down homeopathic effects with direct experimental testing and this places homeopathy in a scientific dilemma. We close with some suggestions for potentially fruitful research.

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Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials

Cited by 98 publications

References 21 publications

A Pilot, Randomized, Double-Blinded, Placebo-Controlled Trial of Individualized Homeopathy for Symptoms of Estrogen Withdrawal in Breast-Cancer Survivors

A Pilot, Randomized, Double-Blinded, Placebo-Controlled Trial of Individualized Homeopathy for Symptoms of Estrogen Withdrawal in Breast-Cancer Survivors

Homotoxicological remedies versus desmopressin versus placebo in the treatment of enuresis: a randomised, double-blind, controlled trial

Research on Homeopathy: State of the Art

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