Homeopathic Treatment of Migraine in Children: Results of a Prospective, Multicenter, Observational Study

Danno, Karine; Colas, Aurélie; Masson, Jean-Louis; Bordet, Marie-France

doi:10.1089/acm.2011.0821

Cited by 26 publications

(18 citation statements)

References 13 publications

(15 reference statements)

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“…Anxiety and depression are among the ailments most frequently reported by patients seeking complementary and alternative medical remedies and/or naturopathic care [9,52,53]. Gelsemium s. is a traditional remedy used in complementary and alternative therapies for treating patients who exhibit neurological complaints such as headache and anxiety-like symptoms [9,52,53], but evidence-based clinical studies are few and with contrasting results [53,54]. …”

Section: Discussionmentioning

confidence: 99%

Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Marzotto

Olioso

Brizzi

et al. 2014

BMC Complement Altern Med

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BackgroundGelsemium sempervirens L. (Gelsemium s.) is a traditional medicinal plant, employed as an anxiolytic at ultra-low doses and animal models recently confirmed this activity. However the mechanisms by which it might operate on the nervous system are largely unknown. This work investigates the gene expression of a human neurocyte cell line treated with increasing dilutions of Gelsemium s. extract.MethodsStarting from the crude extract, six 100 × (centesimal, c) dilutions of Gelsemium s. (2c, 3c, 4c, 5c, 9c and 30c) were prepared according to the French homeopathic pharmacopoeia. Human SH-SY5Y neuroblastoma cells were exposed for 24 h to test dilutions, and their transcriptome compared by microarray to that of cells treated with control vehicle solutions.ResultsExposure to the Gelsemium s. 2c dilution (the highest dose employed, corresponding to a gelsemine concentration of 6.5 × 10-9 M) significantly changed the expression of 56 genes, of which 49 were down-regulated and 7 were overexpressed. Several of the down-regulated genes belonged to G-protein coupled receptor signaling pathways, calcium homeostasis, inflammatory response and neuropeptide receptors. Fisher exact test, applied to the group of 49 genes down-regulated by Gelsemium s. 2c, showed that the direction of effects was significantly maintained across the treatment with high homeopathic dilutions, even though the size of the differences was distributed in a small range.ConclusionsThe study shows that Gelsemium s., a medicinal plant used in traditional remedies and homeopathy, modulates a series of genes involved in neuronal function. A small, but statistically significant, response was detected even to very low doses/high dilutions (up to 30c), indicating that the human neurocyte genome is extremely sensitive to this regulation.

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Section: Discussionmentioning

confidence: 99%

Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Marzotto

Olioso

Brizzi

et al. 2014

BMC Complement Altern Med

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“…The aim of another study was to assess the efficacy of homeopathic remedies for the prevention and treatment of migraine in children [28]. It was an observational, prospective, open, non-randomized, multicenter study.…”

Section: Efficacy Profile Of the Homeopathic Productmentioning

confidence: 99%

Efficacy Profile of the Homeopathic Combination for Influenza and Acute Respiratory Viral Diseases Treatment and Prevention

Bondarenko

Gorchakova

Galkin

2018

Innov Biosyst Bioeng

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Background. Acute respiratory viral infection (ARVI) is accompanied by a general intoxication syndrome and respiratory mucosa predominant damage. A significant number of viral nature pathogens from various nosological groups (influenza viruses, parainfluenza, adenoviruses, respiratory syncytial viruses, coronaviruses, picornaviruses, rhinoviruses, enteroviruses, herpesviruses, etc.) could cause development of ARVI at human respiratory tract. Methods of ethnoscience and non-traditional medicine can be used as part of integrated treatment and prevention of influenza and ARVI. With the help of anti-cold homeopathic remedies, people can be treated from the very beginning of the disease when an elevated temperature is observed and there are all signs of intoxication and inflammation. Objective. Scientific justification for the safety and efficacy of a complex homeopathic formulation in tablet form (Aconitum napellus D6, Ammonium bromatum D4, Atropa belladonna D6, Bryonia D6, Cinchona pubescens D6, Echinacea D3, Hydrargyrum bicyanatum D8, Rhustoxicodendron D6) intended to enhance the natural immunity in influenza and respiratory diseases, to normalize the functional state of the immune system and upper respiratory tract. Results. Most patients have acute febrile respiratory syndrome, and some population groups have an increased risk of complications in the form of severe illness or death. These groups include elderly people, very young people, and people with concomitant illnesses. Annually, every third inhabitant of the planet suffers from acute respiratory infections. We have conducted a scientific substantiation of the safety and efficacy of a complex homeopathic tablet formulation (Aconitum napellus D6, Ammonium bromatum D4, Atropa belladonna D6, Bryonia D6, Cinchona pubescens D6, Echinacea D3, Hydrargyrum bicyanatum D8, Rhustoxicodendron D6), which can be used to treat and prevention of these diseases. Conclusions. Components of developed homeopathic preparation are used in medical practice as anti-cold and immunomodulating mono-and complex homeopathic preparations for more than 100 years. There are no restrictions on the use of the drug in the context of its safety profile, since the active ingredient concentrations used are completely non-toxic. The preparation enhances the body's protective responses and promotes the relief of symptoms of acute respiratory infections and flu (headache, sneezing, runny nose, sore throat, body aches, fever) and rapid recovery.

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“…18 Furthermore, homeopathic therapies, also commonly used in the treatment of migraine have been also suggested to result in a significant decrease in frequency, severity, and duration of pediatric migraine attacks. 19 Notably, however, both acupuncture and homeopathic interventions do not seem to perform better than placebos in controlled clinical trials. 20,21 The observable beneficial responses resulting from these interventions most likely are a reflection of the placebo effect, perhaps enhanced by a more elaborate administration ritual bordering on spiritual beliefs in the efficacy of the remedy, a close patient-practitioner interaction, and the practitioner’s belief in the treatment.…”

Section: Treating Pediatric Migrainementioning

confidence: 99%

“…2 Moreover, as stated above, the non-pharmacological and alternative interventions considered to be driven by placebo mechanisms, seem to be particularly effective in pediatric populations. 19 Therefore, instead of focusing on eliminating placebo responses in clinical migraine trials, the focus should be redirected towards understanding the underlying mechanism responsible for high placebo response rates in children with migraine (after excluding confounding factors such as spontaneous remission) in order to maximize that mechanism and use it therapeutically.…”

Section: Placebo Responses In Clinical Trials Of Pediatric Migrainementioning

confidence: 99%

Harnessing the Placebo Effect in Pediatric Migraine Clinic

Faria¹,

Linnman²,

Lebel³

et al. 2014

The Journal of Pediatrics

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Homeopathic Treatment of Migraine in Children: Results of a Prospective, Multicenter, Observational Study

Abstract: The results of this study demonstrate the interest of homeopathic medicines for the prevention and treatment of migraine attacks in children. A significant decrease in the frequency, severity, and duration of migraine attacks was observed and, consequently, reduced absenteeism from school.

Cited by 26 publications

References 13 publications

Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Efficacy Profile of the Homeopathic Combination for Influenza and Acute Respiratory Viral Diseases Treatment and Prevention

Harnessing the Placebo Effect in Pediatric Migraine Clinic

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