Homeopathic treatment as an alternative prophylactic to minimize bacterial infection and prevent neonatal diarrhea in calves

Fortuoso, Bruno F.; Volpato, Andréia; Rampazzo, Luana; Glombowsky, Patrícia; Griss, Luiz Gustavo; Galli, Gabriela M.; Stefani, Lenita M.; Baldissera, Matheus D.; Ferreira, Emanuel B.; Machado, Gustavo; Silva, Aleksandro S. Da

doi:10.1016/j.micpath.2017.11.041

Cited by 15 publications

(8 citation statements)

References 10 publications

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“…A decrease of more than 8% body weight is believed to require intravenous (iv) fluids rather than exclusive oral fluids for successful rehydration [9]. In addition to classical therapy, alternatives such as the homeopathic treatment [10] or the use of chestnut extract have been proposed [11].…”

Section: Introductionmentioning

confidence: 99%

The Use of Activated Micronized Zeolite Clinoptilolite as a Possible Alternative to Antibiotics and Chestnut Extract for the Control of Undifferentiated Calf Diarrhea: An In Vitro and In Vivo Study

Cerbu

Ilaș

Czopowicz

et al. 2020

Animals

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Today, zeolite appears as an interesting alternative for the symptomatic treatment of acute diarrhea. Therefore, this study aimed to investigate the properties of activated micronized (5 microns) zeolite clinoptilolite (MZC) from Transylvania, Romania, first by testing it in vitro and then in vivo on calves with diarrhea. To assess the toxic potential of the MZC, we performed a cell cytotoxicity assay using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) technique on primary bovine intestinal epithelial cells (BIECs). The antimicrobial activity of MZC was investigated by measuring the minimal inhibitory concentration (MIC) on Escherichia coli (ATCC 25922). The uncontrolled in vivo study was carried out over 8 days on a fattening farm, with some 650 calves. Selected calves were randomly assigned to four groups of 20 individuals. Several combinations between MZC, chestnut extract, and oxytetracycline were tested. At the beginning of the study, all calves had diarrhea, while at the end of the study, the prevalence of diarrhea was significantly lower in all four groups (p < 0.001), including the ones treated with MZC. Due to its low cytotoxicity on the intestinal cells and with regards to the results we obtained in vivo, MZC may be considered an alternative for the symptomatic treatment of undifferentiated diarrhea in calves.

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Section: Introductionmentioning

confidence: 99%

The Use of Activated Micronized Zeolite Clinoptilolite as a Possible Alternative to Antibiotics and Chestnut Extract for the Control of Undifferentiated Calf Diarrhea: An In Vitro and In Vivo Study

Cerbu

Ilaș

Czopowicz

et al. 2020

Animals

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“…The use of homeopathic agents has been increasing in recent years. These agents function as immunological stimulants (Mazón-Suástegui et al, 2017), and they have direct effects on the control of diarrhea, decreasing the count of pathogenic bacteria in the feces of calves and lambs (Fortuoso et al, 2018;. Phytotherapeutics and minerals are used in mixtures of homeopathic compounds because of their immunological properties (Kayne, 1992).…”

Section: Discussionmentioning

confidence: 99%

Addition of a homeopathic, preventive product for mastitis in dairy cow feed: effects on etiologic agents, animal health, production, composition, and quality of milk

Defiltro

Glombowsky

Girardini

et al. 2020

RSD

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The aim of this study was to determine whether the addition of a homeopathic product to dairy cow feed would improve health and production efficiency, as well as composition and quality of milk. The product tested here was produced to stimulate immunity and indirectly to prevent the colonization of the mammary gland by bacteria, thereby decreasing somatic cell counts and bacteria in cow’s milk. Fifty dairy cows were used, divided into two groups: Control (n = 25) and Treated (n = 25). For 90 consecutive days, 50 grams of homeopathic product (treated group) was added to the concentrate; 50 g of the product vehicle (limestone) was added to the concentrate of the control cows. We performed composition and quality analysis on the milk (days 1, 15, 30, 45, 60, 75, and 90) as well as blood collection to carry out hematological and metabolism analyses (days 1, 30, 60, and 90). We found that fat content in the milk cows consuming the homeopathic agent was greater than that of the control group. Because of this increased fat content, there was a tendency towards higher total solids content in treated cows. A treatment effect was found in terms of total bacterial count (TBC); that is, there were lower TBCs in milk of treated animals than in control animals. There was a trend of a treatment effect versus day for somatic cell count (SCC); that is, there were lower SCC in animals that consumed the homeopathic on days 15 and 30 of the experiment. There was no difference between groups in terms of milk production; however, there was a negative correlation between milk production and TBC or SCC in the milk of cows that consumed homeopathic product. Animals in the treated group had lower total leukocyte and lymphocyte counts than did the control group, as well as a tendency toward lower neutrophil counts in these animals. Several bacteria were isolated from the cows' milk during the experimental period, with no treatment effect. In particular, we isolated Corynebacterium spp., Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus hyicus in greater numbers of cows compared to other etiologic agents. Based on these results, we conclude that consumption of the homeopathic product by dairy cows had positive effects on milk quality.

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“…En animales de granja, la venta de productos para el control de la diarrea en animales jóvenes también ha crecido, y algunos estudios han demostrado su efectividad. (14) utilizaron un producto homeopático preventivo en terneros lactantes, una fase en la que se observan altas tasas de diarrea en animales; los autores encontraron un 50% de eficacia en la prevención de la diarrea y un 80% en la reducción del uso de antimicrobianos en animales que reciben productos homeopáticos. Se encontró un resultado similar en corderos lecheros alimentados con leche descartada (15).…”

Section: Reporte De Casounclassified

“…Para minimizar los impactos de la diarrea causada por Giardia sp., se han buscado productos alternativos, incluidos los preventivos y los productos curativos homeopáticos que tratan la diarrea (12). La prevención y el tratamiento de la enteritis con homeopatía en animales de granja han mostrado buenos resultados (13,14,15). Sin embargo, para las mascotas, no se han estudiado los efectos de los agentes antiparasitarios combinados con agentes homeopáticos para el tratamiento de Giardia.…”

Section: Introductionunclassified

Uso de secnidazol y homeopatía para el control de giardiasis en perros

et al. 2020

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Dogs with Giardia infections have diarrhea that persists for days, even after treatment. We managed canine giardiasis using two distinct approaches: treatment with the antiprotozoan secnidazole alone; and secnidazole plus a homeopathic product that is indicated for control of diarrhea in dogs. Treatment I: Ten beagle dogs showed clinical signs of severe diarrhea. Their feces revealed large numbers of cysts consistent with Giardia sp. Therefore, we treated the dogs with secnidazole (10 mg/kg, single dose) given orally. Five days after treatment, all dogs were negative for Giardia spp. Treatment II: Three months later, the same ten Beagles again presented with diarrhea. Feces were collected, revealing Giardia sp. in all dogs. This time, we treated them with an antiprotozoan (secnidazole, 10 mg/kg dose) combined with a commercial homeopathic drug for diarrhea control (3 g dose/animal at 12 h interval). We found that three to five homeopathic doses were needed to achieve normal fecal scores in all dogs. After 5 days of treatment, stool samples had normal consistency and were negative for Giardia. This is the first record of using secnidazole to control canine giardiasis associated with homeopathic drugs to prevent diarrhea.

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Homeopathic treatment as an alternative prophylactic to minimize bacterial infection and prevent neonatal diarrhea in calves

Cited by 15 publications

References 10 publications

The Use of Activated Micronized Zeolite Clinoptilolite as a Possible Alternative to Antibiotics and Chestnut Extract for the Control of Undifferentiated Calf Diarrhea: An In Vitro and In Vivo Study

The Use of Activated Micronized Zeolite Clinoptilolite as a Possible Alternative to Antibiotics and Chestnut Extract for the Control of Undifferentiated Calf Diarrhea: An In Vitro and In Vivo Study

Addition of a homeopathic, preventive product for mastitis in dairy cow feed: effects on etiologic agents, animal health, production, composition, and quality of milk

Uso de secnidazol y homeopatía para el control de giardiasis en perros

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