Homeobox Genes Hoxd3 and Hoxd8 Are Differentially Expressed in Fetal Mouse Excisional Wounds

Jain, Kunoor; Sykes, Virginia W.; Kordula, Tomasz; Lanning, David A.

doi:10.1016/j.jss.2008.02.053

Cited by 15 publications

(12 citation statements)

References 10 publications

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“…49 Hoxd8 expression is also increased in mid-gestational wounds, suggesting that it may play a role in scarless wound repair. 50 Msx-1 and Msx-2 are other homeobox genes and are expressed in the fingertips in mice. The regenerative ability of mouse fingertips is restricted to areas in which the amputation plane is within the region of Msx1 expression.…”

Section: (3) Other Moleculesmentioning

confidence: 99%

Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin

et al. 2012

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Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, inflammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration.

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Section: (3) Other Moleculesmentioning

confidence: 99%

Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin

et al. 2012

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“…A number of Hox genes are expressed in both fetal and adult skin [96, 97], however, fetal wounds show an increase in expression of a number of the Hox genes during fetal scarless repair [98, 99]. Though HoxB 13 was downregulated in fetal scarless wounds [99] and in an adult model, Hoxb13 knockout animals showed a more fetal-like healing phenotype [100].…”

Section: Cell Signalling Transcription and Gene Expressionmentioning

confidence: 99%

A Review of Fetal Scarless Healing

Rolfe

Grobbelaar

2012

ISRN Dermatology

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“…In a recent study, Jain et al. 33 reported the increased expression of Hox gene Hoxd8 in excisional wounds of mid‐gestational mice compared with the normal skin samples of mid‐gestational mice and excisional wounds of late‐gestational mice; therefore, it is proposed that this gene may have anti‐scarring effects in fetal wound healing. Conversely, expression of another Hox gene Hoxd3 was found to be increased in both excisional wounds and normal skin samples of mid‐gestational mice compared with late‐gestational mice; hence, this gene is considered to be expressed constitutively in the skin of mid‐gestational mice.…”

Section: Scarless Wound‐healing Physiologymentioning

confidence: 99%

Strategies for prevention of scars: what can we learn from fetal skin?

2010

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Fetal wound healing occurs rapidly and without scar formation early in gestation.Studying the mechanisms of scarless repair can lead to novel scar-preventive approaches. In fetal wounds, collagen is deposited early and is fine and reticular with less cross-linking. Several important differences of fetal vs. postgestational wound-healing response have been determined, such as the presence of less inflammation, higher hyaluronic acid concentration and a greater ratio of collagen type III to type I. Compared with typical wounds, there are also altered ratios of signaling molecules, such as higher ratios of transforming growth factor (TGF)-b3 to TGF-b1 and -b2, and matrix metalloproteinases to tissue inhibitors of metalloproteinases. Furthermore, fetal fibroblasts do not exhibit TGF-b1-induced collagen production compared with their mature counterparts.Patterning genes (homeobox genes) involved in organogenesis are more active in the fetal period and are believed to be the ''first domino'' in the fetal cutaneous wound repair regulatory cascade. The recommended scar-preventive agents, such as Scarguard MD â , silicone gel and sheet, Seprafilm â Bioresorbable Membrane, topical hyaluronan, onion extract, oral tamoxifen and 585-nm pulsed dye laser are reviewed in this study. Despite the lack of supporting evidence, there is a widespread false presumption that the acceleration of healing with the widely assumed scar-preventive commercial agents is associated with decreased scar formation. Humans are erroneously inclined to make a negative correlation between the healing rate and the degree of scar formation, while such a correlation does not exist in reality. Despite the importance of scar prevention, no FDA-approved therapy for this purpose is available in the 21st century, which reflects the important challenges, such as the presence of redundant pathways, that these approaches are facing.

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Homeobox Genes Hoxd3 and Hoxd8 Are Differentially Expressed in Fetal Mouse Excisional Wounds

Cited by 15 publications

References 10 publications

Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin

Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin

A Review of Fetal Scarless Healing

Strategies for prevention of scars: what can we learn from fetal skin?

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