Homeobox genes for embryo implantation: From mouse to human

He, Bo; Ni, Zhangli; Kong, Shuangbo; Lu, Jinhua; Wang, Haibin

doi:10.1002/ame2.12002

Cited by 31 publications

(20 citation statements)

References 100 publications

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“…In recent years, the incidence of uterine disease in dairy cows has shown an increasing trend, and has become one of the most important factors affecting their reproductive efficiency ( 1 ). The endometrium plays an essential role in embryo implantation, embryo development, and sperm motility ( 2 ). Endometritis is a type of refractory uterine disease, which is mainly caused by pathogenic microorganisms (such as Escherichia coli and Streptococcus ) infecting the endometrium during or after parturition ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows

Liu

et al. 2021

Front. Vet. Sci.

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Endometritis is a disease that affects reproductive health in dairy cows and causes serious economic damage to the dairy industry world-wide. Although in recent years, the application of mesenchymal stem cell (MSC) therapy for the treatment of inflammatory diseases has attracted much attention, there are few reports of the use of MSCs in dairy cows. In the present study, our objective was to explore the inhibitory effects of bovine adipose-derived mesenchymal stem cells (bAD-MSCs) on lipopolysaccharide (LPS) induced inflammation in bovine endometrial epithelial cells (bEECs) along with the potential underlying molecular mechanisms. We characterized isolated bAD-MSCs using cell surface marker staining and adipogenic/osteogenic differentiation, and analyzed them using immunofluorescence, flow cytometry (surface marker staining), and adipogenic and osteogenic differentiation. Furthermore, to understand the anti-inflammatory effects of bAD-MSCs on LPS induced bEEC inflammation, we used a bAD-MSC/bEEC co-culture system. The results showed that bAD-MSC treatments could significantly decrease LPS induced bEEC apoptosis and pro-inflammatory cytokine expression levels, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Furthermore, our results showed that bAD-MSC treatments could also significantly downregulate LPS induced p38, IkB-a, and JAK1 phosphorylation and Bax protein expression levels, which are closely related to inflammatory progress and cellular apoptosis in bEECs. Our findings demonstrate that bAD-MSCs play an inhibitory role in LPS induced bEEC inflammation and provide new insights for the clinical therapy of endometritis in dairy cows.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows

Liu

et al. 2021

Front. Vet. Sci.

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“…Cermik et al have shown that HOXA10 is involved in the regulation of progesterone's transcription targets and in the regulation of endometrial receptivity. The reduction of HOXA10 expression in the uterus might be one of the important reasons for progesterone resistance, poor endometrial receptivity, and reduced reproductive potential in patients with PCOS (He et al, 2018). In summary, progesterone resistance is an important mechanism leading to poor endometrial receptivity, endometrial dysplasia, and even endometrial cancer in patients with PCOS.…”

Section: )mentioning

confidence: 98%

Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium

Zhang

Feng

et al. 2021

Front. Physiol.

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As a highly dynamic tissue, the endometrium is periodically shed in response to the secretion of estrogen and progesterone. After menarche, the endometrium of healthy women proliferates and differentiates under the action of steroid hormones (e.g., 17β-estradiol and progesterone) that are secreted by the ovaries to provide appropriate conditions for embryo implantation. Polycystic ovary syndrome (PCOS), a prevalent endocrine and metabolic disorder in reproductive-aged women, is usually associated with multiple cysts within the ovaries and excess levels of androgen and is characterized by hirsutism, acne, menstrual irregularity, infertility, and increased risk of insulin resistance. Multiple factors, such as anovulation, endocrine-metabolic abnormalities, and inflammation, can disrupt the endometrium in PCOS patients and can lead to endometrial hyperplasia, pregnancy complications, or even cancer. Despite many recent studies, the relationship between PCOS and abnormal endometrial function is still not fully understood. In this review, we investigate the correlation of PCOS patient endometrium with anovulation, hyperandrogenemia, insulin resistance, progesterone resistance, and inflammatory cytokines, aiming to provide a theoretical basis for the treatment of disorders caused by endometrial dysfunction in PCOS patients.

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“…Correspondingly, women with infertility exhibit a significantly reduced expression of ERb (69,70). In addition to nuclear receptor transcription factors, such as ER and PR, studies on knockout mice have shown that multiple transcription factors, including Hox family transcription factors, Msx transcription factors, and Kruppel-like transcription factors, also regulate uterine receptivity (71)(72)(73)(74)(75)(76)(77)(78). In the reproductive system, Hox genes are known to be widely involved in the development of mouse and human reproductive systems, and consequently in the maintenance of early pregnancy.…”

Section: Potential Factors Affecting Endometrial Functionmentioning

confidence: 99%

Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights

Lin

Kong

2021

Front. Endocrinol.

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The human endometrium plays a vital role in providing the site for embryo implantation and maintaining the normal development and survival of the embryo. Recent studies have shown that stress is a common factor for the development of unexplained reproductive disorders. The nonreceptive endometrium and disturbed early maternal-fetal interaction might lead to infertility including the repeated embryo implantation failure and recurrent spontaneous abortion, or late pregnancy complications, thereby affecting the quality of life as well as the psychological status of the affected individuals. Additionally, psychological stress might also adversely affect female reproductive health. In recent years, several basic and clinical studies have tried to investigate the harm caused by psychological stress to reproductive health, however, the mechanism is still unclear. Here, we review the relationship between psychological stress and endometrial dysfunction, and its consequent effects on female infertility to provide new insights for clinical therapeutic interventions in the future.

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Homeobox genes for embryo implantation: From mouse to human

Cited by 31 publications

References 100 publications

Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows

Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows

Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium

Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights

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